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CAS No 25812-30-0 , 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid

  • Name: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
  • Synonyms: Bolutol;Lopid; Gemfibromax; Lipur;5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid; Apo-Gemfibrozil; Fibratol; Cholespid; Jezil; Decrelip;
  • CAS Registry Number:
  • Density: 1.044
  • Refractive index: 1.511
  • Safety Statements: S36;S53;S36/37;S26;S25;
  • Hazard Symbols: Xn,Xi
  • EINECS: 247-280-2
  • Molecular Weight: 250.33338
  • InchiKey: HEMJJKBWTPKOJG-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,
    10H,5,8-9H2,1-4H3,(H,16,17)
  • Risk Statements: 22-63-62-46-36/38-21
  • Molecular Formula: C15H22O3
  • Molecular Structure:CAS No:25812-30-0 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid

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References of 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
Title: Gemfibrozil
CAS Registry Number: 25812-30-0
CAS Name: 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
Synonyms: 2,2-dimethyl-5-(2,5-xylyloxy)valeric acid
Manufacturers' Codes: CI-719
Trademarks: Decrelip (Ferrer); Genlip (Teofarma); Gevilon (Pfizer); Lipozid (Pfizer); Lipur (Pfizer); Lopid (Pfizer)
Molecular Formula: C15H22O3
Molecular Weight: 250.33
Percent Composition: C 71.97%, H 8.86%, O 19.17%
Literature References: Serum lipid regulating agent. Prepn: P. L. Creger, DE 1925423; eidem, US 3674836 (1969, 1972, both to Parke, Davis). Production: O. P. Goel, US 4126637 (1978 to Warner-Lambert). Pharmacology: A. H. Kissebach et al., Atherosclerosis 24, 199 (1976); M. T. Kahonen et al., ibid. 32, 47 (1979). Series of articles on metabolism, clinical pharmacology, kinetics and toxicology: Proc. R. Soc. Med. 69, Suppl 2, 1-120 (1976). Toxicity data: S. M. Kurtz et al., ibid. 15. Clinical trial in hyperlipidemia: J. E. Lewis et al., Pract. Cardiol. 9, 99 (1983). Clinical reduction of cardiovascular risk in patients with low HDL levels: H. B. Rubins et al., N. Engl. J. Med. 341, 410 (1999).
Properties: Crystals from hexane, mp 61-63°. bp0.02 158-159°. LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz).
Melting point: mp 61-63°
Boiling point: bp0.02 158-159°
Toxicity data: LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz)
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.