CAS No 24870-04-0 , a1-18-Corticotropin,1-glycine-18-L-argininamide- (8CI,9CI)

Name: a1-18-Corticotropin,1-glycine-18-L-argininamide- (8CI,9CI)
Synonyms: 50022S;Giractide;a1-18-Corticotropin,1-glycine-18-L-argininamide- (8CI,9CI);1-Glycine-a1-18-corticotropin amide;H-Gly-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-NH2;
CAS Registry Number:24870-04-0
Molecular Weight: 2218.61
InChI: InChI=1/C100H156N34O22S/c1-56(2)82(96(155)118-53-79(138)120-65(23-9-12-37-101)85(144)124-66(24-10-13-38-102)87(146)125-67(27-16-41-114-99(108)109)86(145)123-64(83(105)142)26-15-40-113-98(106)107)133-95(154)77-29-18-43-134(77)97(156)71(25-11-14-39-103)121-80(139)52-117-84(143)74(47-59-50-116-63-22-8-7-21-62(59)63)130-88(147)68(28-17-42-115-100(110)111)126-92(151)73(45-57-19-5-4-6-20-57)129-93(152)75(48-60-51-112-55-119-60)131-89(148)69(34-35-81(140)141)127-90(149)70(36-44-157-3)128-94(153)76(54-135)132-91(150)72(122-78(137)49-104)46-58-30-32-61(136)33-31-58/h4-8,19-22,30-33,50-51,55-56,64-77,82,116,135-136H,9-18,23-29,34-49,52-54,101-104H2,1-3H3,(H2,105,142)(H,112,119)(H,117,143)(H,118,155)(H,120,138)(H,121,139)(H,122,137)(H,123,145)(H,124,144)(H,125,146)(H,126,151)(H,127,149)(H,128,153)(H,129,152)(H,130,147)(H,131,148)(H,132,150)(H,133,154)(H,140,141)(H4,106,107,113)(H4,108,109,114)(H4,110,111,115)/t64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,82-/m0/s1
Molecular Formula: C100H156 N34 O22 S
Molecular Structure:

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References of a1-18-Corticotropin,1-glycine-18-L-argininamide- (8CI,9CI)

Title: Giractide
CAS Registry Number: 24870-04-0
CAS Name: 1-Glycine-18-L-argininamide-a(1-18)-corticotropin
Molecular Formula: C100H156N34O22S
Molecular Weight: 2218.59
Percent Composition: C 54.14%, H 7.09%, N 21.47%, O 15.87%, S 1.45%
Literature References: Polypeptide corresp to the first 18 amino acid residues in corticotropin, in which the 1-serine is replaced by glycine. Prepn: H. Otsuka et al., Bull. Chem. Soc. Jpn. 43, 196 (1970); of the hexaacetate: eidem, JP 70 19061 (1970 to Shionogi), C.A. 73, 110138r (1970). Adrenocorticotropic potency in man: J. Clin. Endocrinol. Metab. 33, 355 (1971). Fluorometric study: T. Muraki et al., Experientia 32, 1605 (1976). Absorption: M. Hirata et al., Chem. Pharm. Bull. 26, 1061 (1978). Chromatographic studies: S. Terabe et al., J. Chromatogr. 172, 163 (1979); M. Schoeneshoefer, A. Fenner, ibid. 224, 472 (1981).
Properties: [a]D23.5 -51.4 ±1.9° (c = 0.472 in 0.1N acetic acid). uv max (0.1N NaOH): 281, 288 nm (e 6750, 6490).
Optical Rotation: [a]D23.5 -51.4 ±1.9° (c = 0.472 in 0.1N acetic acid)
Absorption maximum: uv max (0.1N NaOH): 281, 288 nm (e 6750, 6490)

Derivative Type: Hexaacetate salt
CAS Registry Number: 29365-11-5
Manufacturers' Codes: S-50022
Trademarks: Acthormon (Shionogi)
Molecular Formula: C100H156N34O22S.6C2H4O2
Molecular Weight: 2578.90
Percent Composition: C 52.16%, H 7.04%, N 18.47%, O 21.09%, S 1.24%

Therap-Cat: Adrenocorticotropic hormone.
Keywords: Adrenocorticotropic Hormone.