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CAS No 24526-64-5 , 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine

  • Name: 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine
  • Synonyms: (+-)-Nomifensine; Linamiphen; (+-)-Nomifensin;2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine; Nomifenison; Nomifensina; (+)-Nomiphensine; (+)-Nomifensine;nomifensin;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 238.328
  • Flash Point: 164°C
  • Boiling Point: 378.4°Cat760mmHg
  • Density: 1.114g/cm3
  • Refractive index: 1.622
  • Safety Statements: Poison by ingestion and intravenous routes. Human systemic effects by ingestion: diffuse hepatitis, hemorrhage and decrease in the number of blood platelets (thrombocytopenia). When heated to decomposition it emits toxic fumes of NOx. See also NOMIFENSINE MALEATE.
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 164°C
  • Molecular Weight: 238.32752
  • InchiKey: XXPANQJNYNUNES-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H18N2/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-
    18/h2-9,14H,10-11,17H2,1H3
  • Risk Statements: 22-36/37/38
  • Molecular Formula: C16H18N2
  • Molecular Structure:CAS No:24526-64-5 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine

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References of 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine
Title: Nomifensine
CAS Registry Number: 24526-64-5
CAS Name: 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine
Synonyms: 8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline
Molecular Formula: C16H18N2
Molecular Weight: 238.33
Percent Composition: C 80.63%, H 7.61%, N 11.75%
Literature References: Novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure. Prepn: GB 1164192 corresp to G. Ehrhart et al., US 3577424 (1969, 1971, both to Farbwerke Hoechst); I. Hoffmann et al., Arzneim.-Forsch. 21, 1045 (1971). Pharmacology: I. Hoffmann, ibid. 23, 45 (1973); P. Hunt et al., J. Pharm. Pharmacol. 26, 370 (1974); B. Costall et al., Psychopharmacologia 41, 153 (1975). Pharmacokinetics: L. Vereczkey et al., ibid. 45, 225 (1975). Study on abuse potential in humans: C. Spyraki, H. C. Fibiger, Science 212, 1167 (1981). Review: Br. J. Clin. Pharmacol. 4, Suppl. 2 (1977) pp 1S-248S; Int. Pharmacopsychiatry 17, Suppl. 1 (1982) pp 1-148.
Properties: mp 179-181°.
Melting point: mp 179-181°
 
Derivative Type: Maleate
CAS Registry Number: 32795-47-4
Manufacturers' Codes: HOE-984
Trademarks: Alival (Hoechst); Hostalival (Hoechst); Merital (Hoechst); Neurolene (Magis); Psicronizer (Albert-Pharma)
Molecular Formula: C16H18N2.C4H4O4
Molecular Weight: 354.40
Percent Composition: C 67.78%, H 6.26%, N 7.90%, O 18.06%
Properties: Crystals from ethanol, mp 199-201°. LD50 in mice, rats (mg/kg): 400, 430 orally; 90, 72 i.v.; in mice (mg/kg): 410 s.c. (Hoffman, 1973).
Melting point: mp 199-201°
Toxicity data: LD50 in mice, rats (mg/kg): 400, 430 orally; 90, 72 i.v.; in mice (mg/kg): 410 s.c. (Hoffman, 1973)
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Bicyclics.