CAS No 23239-41-0 , Cefacetrile sodium

Name: Cefacetrile sodium
Synonyms: Sodium (6R,7R)-3-(acetyloxymethyl)-7-[(2-cyanoacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Cefacetrile sodium;Cephacetrile sodium;
CAS Registry Number:23239-41-0
Flash Point: 412°C
Boiling Point: 757.5°Cat760mmHg
Density: g/cm³
Safety Statements: Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intramuscular routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, SOx, Na2O, and CN−. See also NITRILES.
Flash Point: 412°C
EINECS: 245-513-2
Molecular Weight: 361.31
InChI: InChI=1/C13H13N3O6S.Na/c1-6(17)22-4-7-5-23-12-9(15-8(18)2-3-14)11(19)16(12)10(7)13(20)21;/h9,12H,2,4-5H2,1H3,(H,15,18)(H,20,21);/q;+1/p-1/t9-,12-;/m1./s1
Molecular Formula: C13H12N3NaO6S
Molecular Structure:

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23239-41-0 Cephacetrile Sodium

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23239-41-0 CEFACETRILE SODIUM

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References of Cefacetrile sodium

Title: Cephacetrile Sodium
CAS Registry Number: 23239-41-0
CAS Name: (6R,7R)-3-[(Acetyloxy)methyl]-7-[(cyanoacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt
Synonyms: sodium 7-(2-cyanoacetamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate acetate (ester); sodium 7-(2-cyanoacetamido)cephalosporanic acid
Manufacturers' Codes: Ciba 36278-Ba
Trademarks: Celospor (Novartis); Ubrocef (Novartis); Vetimast (Novartis)
Molecular Formula: C13H12N3NaO6S
Molecular Weight: 361.31
Percent Composition: C 43.21%, H 3.35%, N 11.63%, Na 6.36%, O 26.57%, S 8.87%
Literature References: Semi-synthetic cephalosporin antibiotic. Prepn: NL 6600586; Bickel et al., US 3483197 (1966, 1969 both to Ciba). Activity studies: Knüsel et al., Antimicrob. Agents Chemother. 1970, 140; Neu et al., J. Antibiot. 25, 400 (1972). Pharmacokinetics and clinical results: Kradolfer et al., Schweiz. Med. Wochenschr. 103, 711 (1973); Riess et al., ibid. 718. Toxicology: Kradolfer et al., Antimicrob. Agents Chemother. 1970, 150. Review: Arzneim.-Forsch. 24, 1446-1533 (1974).
Properties: White crystalline powder. LD50 in mice (mg/kg): 4500 ± 540 i.v.; 9100 ± 1500 s.c. (Kradolfer).
Toxicity data: LD50 in mice (mg/kg): 4500 ± 540 i.v.; 9100 ± 1500 s.c. (Kradolfer)

Derivative Type: Free acid
Properties: Needles from acetone + ether, mp 168-170° (dec). uv max (0.1N NaHCO3): 260 nm (e 9300).
Melting point: mp 168-170° (dec)
Absorption maximum: uv max (0.1N NaHCO3): 260 nm (e 9300)

Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.