Home > Name List By 4 > 4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxyphenol

CAS No 22950-29-4 , 4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxyphenol

  • Name: 4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxyphenol
  • Synonyms: Dimetofrinum;4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxyphenol; Dimetofrine (INN); Dimetofrina;Dimetofrine; Dimethophrine; Anassicol; 4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxyphenol; 22950-29-4;
  • CAS Registry Number:
  • Flash Point: 203.2°C
  • Boiling Point: 412.3°Cat760mmHg
  • Density: 1.182g/cm3
  • Refractive index: 1.545
  • Flash Point: 203.2°C
  • EINECS: 245-348-6
  • Molecular Weight: 227.25698
  • InchiKey: ZKGDBJAHIIXDDW-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H17NO4/c1-12-6-8(13)7-4-9(15-2)11(14)10(5-7)16-3/h4-5,8,
    12-14H,6H2,1-3H3
  • Molecular Formula: C11H17NO4
  • Molecular Structure:CAS No:22950-29-4 4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxyphenol

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References of 4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxyphenol
Title: Dimetofrine
CAS Registry Number: 22950-29-4
CAS Name: 4-Hydroxy-3,5-dimethoxy-a-[(methylamino)methyl]benzenemethanol
Synonyms: 1-(3,5-dimethoxy-4-hydroxyphenyl)-2-(methylamino)ethanol; dimethophrine; dimetrophine
Molecular Formula: C11H17NO4
Molecular Weight: 227.26
Percent Composition: C 58.14%, H 7.54%, N 6.16%, O 28.16%
Literature References: Selective a1-adrenergic receptor agonist. Prepn: GB 1145637; M. Giani et al., US 3646144 (1969, 1972 both to Zambeletti). Pharmacology: Scrollini et al., Atti Accad. Med. Lomb. 25, 193, 203 (1970), C.A. 76, 54270a, 54425e (1972). Pharmacokinetics and metabolism: P. Boselli et al., Arzneim.-Forsch. 26, 2038 (1976); M. S. Benedetti et al., ibid. 27, 158 (1977). TLC determn: G. Musumarra et al., J. Chromatogr. 350, 151 (1985). Double blind clinical evaluations: V. Baldrighi et al., Curr. Med. Res. Opin. 9, 78 (1984); U. Marini et al., ibid. 265.
Properties: mp 178° (dec). pK 9.71.
Melting point: mp 178° (dec)
pKa: pK 9.71
 
Derivative Type: Hydrochloride
CAS Registry Number: 22775-12-8
Trademarks: Pressamina (Zambeletti)
Molecular Formula: C11H17NO4.HCl
Molecular Weight: 263.72
Percent Composition: C 50.10%, H 6.88%, N 5.31%, O 24.27%, Cl 13.44%
Properties: mp 171-173°.
Melting point: mp 171-173°
 
Therap-Cat: Antihypotensive.
Keywords: a-Adrenergic Agonist; Antihypotensive.