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CAS No 22760-18-5 , 7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one

  • Name: 7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one
  • Synonyms: 22760-18-5; Sandoz 43-715;7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one; SaH 43-715; BRN 0889725;Arthrex; Proquazona [INN-Spanish]; Proquazonum [INN-Latin]; EINECS 245-203-7; Biarison;
  • CAS Registry Number:
  • Flash Point: 220.3°C
  • Boiling Point: 440.6°Cat760mmHg
  • Density: 1.12g/cm3
  • Refractive index: 1.605
  • Safety Statements: Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 220.3°C
  • EINECS: 245-203-7
  • Molecular Weight: 278.34832
  • InchiKey: JTIGKVIOEQASGT-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-
    5-4-6-8-14/h4-12H,1-3H3
  • Molecular Formula: C18H18N2O
  • Molecular Structure:CAS No:22760-18-5 7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one

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22760-18-5 Proquazone

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References of 7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one
Title: Proquazone
CAS Registry Number: 22760-18-5
CAS Name: 7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone
Synonyms: 1-isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone
Manufacturers' Codes: RU-43-715; Sandoz 43-715
Trademarks: Biarison (Sandoz-Wander)
Molecular Formula: C18H18N2O
Molecular Weight: 278.35
Percent Composition: C 77.67%, H 6.52%, N 10.06%, O 5.75%
Literature References: Prepn: H. Ott, M. Denzer, DE 1805501 corresp to US 3845128 and US 3925548 (1969, 1974 and 1975, all to Sandoz); R. V. Coombs et al., J. Med. Chem. 16, 1237 (1973). Metabolism: M. B. Zucker, Proc. Soc. Exp. Biol. Med. 156, 209 (1977); H. Ott, J. Meier, Scand. J. Rheumatol. Suppl. 21, 12 (1978). Pharmacology: H. U. Gubler, M. Baggiolini, ibid. 8; H. Ott, ibid. 5. Clinical studies: P. Sfikakis, P. Tsachalos, Ther. Umsch. 34, 730 (1977); series of articles in Scand. J. Rheumatol. Suppl. 21, 15-39 (1978). Review of pharmacodynamics, pharmacokinetics and therapeutic efficacy: S. P. Clissold, R. Beresford, Drugs 33, 478-502 (1987).
Properties: Yellow crystals from ethyl acetate, mp 137-138°. Sol in chloroform. Insol in water.
Melting point: mp 137-138°
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal).