Home > Name List By other > [7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3, 4-tetrahydroquinolin-6-yl]methanol

CAS No 21738-42-1 , [7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,
4-tetrahydroquinolin-6-yl]methanol

  • Name: [7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,
    4-tetrahydroquinolin-6-yl]methanol
  • Synonyms: Vansil; UK-4271; UK 4271;[7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,
    4-tetrahydroquinolin-6-yl]methanol; Oxamniquinum; Oxamniquina; Mansil; Oxaminiquine; Oxamniquinum [INN-Latin]; 21738-42-1;
  • CAS Registry Number:
  • Melting Point: 279.335
  • Flash Point: 222.1°C
  • Boiling Point: 443.6°Cat760mmHg
  • Density: 1.174g/cm3
  • Refractive index: 1.56
  • Safety Statements: Poison by ingestion, intraperitoneal and intramuscular routes. Human mutation data reported. An antischistosomal agent. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 222.1°C
  • EINECS: 244-556-4
  • Molecular Weight: 279.33484
  • InchiKey: XCGYUJZMCCFSRP-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H21N3O3/c1-9(2)15-7-12-4-3-10-5-11(8-18)14(17(19)20)6-13(10)
    16-12/h5-6,9,12,15-16,18H,3-4,7-8H2,1-2H3
  • Molecular Formula: C14H21N3O3
  • Molecular Structure:CAS No:21738-42-1 [7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,<br />4-tetrahydroquinolin-6-yl]methanol

Related products

Select to

21738-42-1 6-Quinolinemethanol,1,2,3,4-tetrahydro-2-[[(1-methylethyl)amino]methyl]-7-nitro-

Contact Supplier

Select to

1/1
References of [7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,
4-tetrahydroquinolin-6-yl]methanol
Title: Oxamniquine
CAS Registry Number: 21738-42-1
CAS Name: 1,2,3,4-Tetrahydro-2-[[(1-methylethyl)amino]methyl]-7-nitro-6-quinolinemethanol
Synonyms: 1,2,3,4-tetrahydro-2-[(isopropylamino)methyl]-7-nitro-6-quinolinemethanol; 6-hydroxymethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetrahydroquinoline
Manufacturers' Codes: UK-4271
Trademarks: Mansil (Pfizer); Vansil (Pfizer)
Molecular Formula: C14H21N3O3
Molecular Weight: 279.33
Percent Composition: C 60.20%, H 7.58%, N 15.04%, O 17.18%
Literature References: Prepn: H. C. Richards, ZA 6803636; idem, US 3821228 (1967, 1974 both to Pfizer). Discovery of schistosomicidal activity: H. C. Richards, R. Foster, Nature 222, 581 (1969). Metabolism: N. M. Woolhouse, B. Kaye, Parasitology 15, 111 (1977). Genetic activity: T. M. Ong, Mutat. Res. 55, 43 (1978). In vitro activity: C. J. Chavasse et al., Ann. Trop. Med. Parasitol. 72, 293 (1978). Mutagenicity study: R. P. Batzinger, E. Bueding, J. Pharmacol. Exp. Ther. 200, 1 (1977). Pharmacology: R. Foster, Rev. Inst. Med. Trop. Sao Paulo 15, Suppl. 1, 189 (1973), C.A. 83, 188417g (1975). Clinical study: R. J. Pitchford, M. Lewis, S. Afr. Med. J. 53, 677 (1978). HPLC determn in biological fluids: H. W. Jun, M. A. Radwan, Anal. Lett. 18, 1345 (1985). Comprehensive description: I. Ahmad, et al., Anal. Profiles Drug Subs. 20, 601-625 (1991).
Properties: Pale yellow crystals from isopropanol, mp 147-149°. Sol in acetone, chloroform and methanol. Sol in about 3300 parts of water at 27°C. pH of a 1% soln 8.0-10.0. uv max (methanol) 205.5, 249.5, 389.5 nm (A1%1cm 486, 695, 62.5). LD50 in mice, rabbits (mg/kg): >2000, >1000 i.m., 1300, 800 orally (Foster).
Melting point: mp 147-149°
Absorption maximum: uv max (methanol) 205.5, 249.5, 389.5 nm (A1%1cm 486, 695, 62.5)
Toxicity data: LD50 in mice, rabbits (mg/kg): >2000, >1000 i.m., 1300, 800 orally (Foster)
Therap-Cat: Anthelmintic (Schistosoma).
Keywords: Anthelmintic (Schistosoma).