Title: Neohesperidin Dihydrochalcone
CAS Registry Number: 20702-77-6
CAS Name: 1-[4-[[2-
O-(6-Deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-1-propanone
Synonyms: 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl-2-
O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranoside; neohesperidin DHC; NHDC
Trademarks: Sukor (Calif. Aromatics & Flavor)
Molecular Formula: C28H36O15
Molecular Weight: 612.58
Percent Composition: C 54.90%, H 5.92%, O 39.18%
Literature References: Prepn from naringen, a flavanone glycoside occurring naturally in grapefruit: Horowitz, Gentile,
US 3087821 and
US 3375242 (1963, 1968, both to U.S. Secy. Agr.); Robertson
et al., Ind. Eng. Chem. Prod. Res. Dev. 13, 125 (1974). Sweetening effect: Inglett
et al., J. Food Sci. 34, 101 (1969). Chromatography: Gentile, Horowitz,
J. Chromatogr. 63, 467 (1971); J. F. Fisher,
J. Agric. Food Chem. 25, 682 (1977). Subchronic oral toxicity study: B. A. R. Lina
et al., Food Chem. Toxicol. 28, 507 (1990).
Review: P. J. Pratter,
Perfum. Flavor. 5, 12-18 (1981).
Properties: Crystals from acetone, mp 156-158°. 1000 to 1500 times sweeter than sucrose; 20 times sweeter than saccharin.
Melting point: mp 156-158°
Use: Sweetening agent, especially in chewing gum and dentifrices.
