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CAS No 20449-79-0 , Melittin

  • Name: Melittin
  • Synonyms: Mellitin; Melittin-T;Melittin; Forapine; Bee venom melittin; Forapin; Melittin; Honeybee melittin; Melittin (honeybee); Melittin I;
  • CAS Registry Number:
  • Transport: UN 3462 6.1/PG 1
  • Density: 1.39
  • Safety Statements: 36-45-36/37/39
  • Hazard Symbols: T: Toxic;
  • Molecular Weight: 2846.46266
  • InchiKey: VDXZNPDIRNWWCW-UHFFFAOYSA-N
  • InChI: InChI=1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-
    62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)
    116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90
    (57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)
    147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)
    149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)
    162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119
    (191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85
    (42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86
    (43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81
    (107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,
    171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,
    175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,
    178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,
    185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,
    199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,
    190)(H,169,200)(H4,139,140,143)(H4,141,142,144)
  • Risk Statements: 23/24/25
  • Molecular Formula: C131H229N39O31
  • Molecular Structure:CAS No:20449-79-0 Melittin

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20449-79-0 Melittin

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20449-79-0 Melittin

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20449-79-0 Melittin

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20449-79-0 MELITTIN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of Melittin
Title: Melittin
CAS Registry Number: 20449-79-0
Synonyms: Melittin I; mellitin
Trademarks: Forapin (Mack, Illert.)
Molecular Formula: C131H229N39O31
Molecular Weight: 2846.46
Percent Composition: C 55.28%, H 8.11%, N 19.19%, O 17.42%
Literature References: Strongly basic polypeptide, the principal component of the venom of the honey bee, Apis mellifica (mellifera), comprising 40-50% of the dried venom. A "direct" hemolysin, one of the hemolytic principles present in the venom, the other being "indirect" acting phospholipase A. Sepn and isoln: Neumann et al., Naturwissenschaften 39, 286 (1952); Neumann, Haberman, Arch. Exp. Pathol. Pharmakol. 222, 367 (1954); Habermann, Reiz, Biochem. Z. 341, 451 (1965). Melittin is the first polypeptide whose biological effects can be understood on the basis of its primary structure. Elucidation of structure and correlation with activity: E. Habermann, J. Jentsch, Z. Physiol. Chem. 348, 37 (1967). Conformation studies: R. Bazzo et al., Eur. J. Biochem. 173, 139 (1988). About 10% of the melittin is thought to be formylated at the N-terminus: Kreil, Kreil-Kiss, Biochem. Biophys. Res. Commun. 27, 275 (1967). Isoln and structure of Na-formyl melittin: Lübke et al., Experientia 27, 765 (1971). Synthesis of melittin and related peptides: Lübke, Schr?der, Peptides, H. C. Beyerman, A. van der Linde, W. M. van den Brink, Eds. (North-Holland Publishing Company, Amsterdam, 1967) pp 271-279; Dorman, Markley, J. Med. Chem. 14, 5 (1970); Schr?der et al., Experientia 27, 764 (1971). Solid phase synthesis and purification: M. T. Tosteson et al., Biochemistry 26, 6627 (1987). Review of biochemistry and pharmacology: Habermann, Science 177, 314 (1972).
Properties: Cream white, water soluble powder. [a]D21 -89.52° (c = 0.409).
Optical Rotation: [a]D21 -89.52° (c = 0.409)
Therap-Cat: Antirheumatic.
Keywords: Antiarthritic/Antirheumatic.