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CAS No 203258-60-0 , Brostallicin

  • Name: Brostallicin
  • Synonyms: Brostallicin;BROSTALLICIN;
  • CAS Registry Number:
  • Molecular Weight: 723.589
  • InChI: InChI=1S/C30H35BrN12O5/c1-16(31)25(44)36-17-9-22(41(3)12-17)27(46)38-19-11-24(43(5)14-19)29(48)39-20-10-23(42(4)15-20)28(47)37-18-8-21(40(2)13-18)26(45)34-6-7-35-30(32)33/h8-15H,1,6-7H2,2-5H3,(H,34,45)(H,36,44)(H,37,47)(H,38,46)(H,39,48)(H4,32,33,35)
  • Molecular Formula: C30H35BrN12O5
  • Molecular Structure:CAS No:203258-60-0 Brostallicin

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203258-60-0 Brostallicin

  • Brostallicin, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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References of Brostallicin
Title: Brostallicin
CAS Registry Number: 203258-60-0
CAS Name: N-[5-[[[5-[[[2-[(Aminoiminomethyl)amino]ethyl]amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-[(2-bromo-1-oxo-2-propenyl)amino]-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrole-2-carboxamide
Molecular Formula: C30H35BrN12O5
Molecular Weight: 723.58
Percent Composition: C 49.80%, H 4.88%, Br 11.04%, N 23.23%, O 11.06%
Literature References: DNA minor groove binder; bromoacryloyl derivative of distamycin A, q.v. Prepn: P. Cozzi et al., WO 9804524; eidem, US 6482920 (1998, 2002 both to Pharmacia & Upjohn). LC/MS/MS determn in plasma: S. Calderoli et al., J. Pharm. Biomed. Anal. 32, 601 (2003). Mechanism of action studies: C. Geroni et al., Cancer Res. 62, 2332 (2002); A. Fedier et al., Br. J. Cancer 89, 1559 (2003). Clinical pharmacokinetics and evaluation in advanced solid tumors: A. J. ten Tije et al., Clin. Cancer Res. 9, 2957 (2003); A. C. Lockhart et al., ibid. 10, 468 (2004). Review of clinical development: M. Broggini et al., Anti-Cancer Drugs 15, 1-6 (2004).
 
Derivative Type: Hydrochloride
CAS Registry Number: 203258-38-2
Manufacturers' Codes: PNU-166196
Molecular Formula: C30H35BrN12O5.HCl
Molecular Weight: 760.04
Percent Composition: C 47.41%, H 4.77%, Br 10.51%, N 22.11%, O 10.53%, Cl 4.66%
Properties: Yellow solid. uv max (95% ethanol): 312.0 nm (e 48792).
Absorption maximum: uv max (95% ethanol): 312.0 nm (e 48792)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic.