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CAS No 198821-22-6 , N-[3-[3-[3-Methoxy-4-(5-oxazolyl)phenyl]ureido]benzyl]carbamic acid tetrahy

  • Name: N-[3-[3-[3-Methoxy-4-(5-oxazolyl)phenyl]ureido]benzyl]carbamic acid tetrahy
  • Synonyms: VI-21497; (3S)-tetrahydrofuran-3-yl [3-({[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoyl}amino)benzyl]carbamate;N-[3-[3-[3-Methoxy-4-(5-oxazolyl)phenyl]ureido]benzyl]carbamic acid tetrahy; VX-497;Merimepodib;
  • CAS Registry Number:
  • Density: 1.36g/cm3
  • Refractive index: 1.632
  • Molecular Weight: 452.4599
  • InChI: InChI=1/C23H24N4O6/c1-30-20-10-17(5-6-19(20)21-12-24-14-32-21)27-22(28)26-16-4-2-3-15(9-16)11-25-23(29)33-18-7-8-31-13-18/h2-6,9-10,12,14,18H,7-8,11,13H2,1H3,(H,25,29)(H2,26,27,28)/t18-/m0/s1
  • Molecular Formula: C23H24N4O6
  • Molecular Structure:CAS No:198821-22-6 N-[3-[3-[3-Methoxy-4-(5-oxazolyl)phenyl]ureido]benzyl]carbamic acid tetrahy

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198821-22-6 MERIMEPODIBUM

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of N-[3-[3-[3-Methoxy-4-(5-oxazolyl)phenyl]ureido]benzyl]carbamic acid tetrahy
Title: Merimepodib
CAS Registry Number: 198821-22-6
CAS Name: [[3-[[[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl] carbamic acid (3S)-tetrahydro-3-furanyl ester
Manufacturers' Codes: VX-497
Molecular Formula: C23H24N4O6
Molecular Weight: 452.46
Percent Composition: C 61.05%, H 5.35%, N 12.38%, O 21.22%
Literature References: Inosine 5￠-monophosphate dehydrogenase (IMPDH) inhibitor. Prepn (stereochemistry unspecified): D. M. Armistead et al., WO 9740028; eidem, US 5807876 (1997, 1998 both to Vertex). In vitro antiviral spectrum: W. Markland et al., Antimicrob. Agents Chemother. 44, 859 (2000); immunosuppressive activity: J. Jain et al., J. Pharm. Sci. 90, 625 (2001). Clinical evaluation in hepatitis C: J. G. McHutchison et al., Antiviral Ther. 10, 635 (2005). Review of structure-activity and mechanism of action: M. D. Sintchak, E. Nimmesgern, Immunopharmacology 47, 163-184 (2000); of development and therapeutic potential: G. Tossing, IDrugs 6, 372-376 (2003).
Therap-Cat: Antiviral.
Keywords: Antiviral.