Home > Name List By n > N-[2-[(8S)-2,6,7, 8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide China

CAS No 196597-26-9 , N-[2-[(8S)-2,6,7,
8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide Search by region : China

  • Name: N-[2-[(8S)-2,6,7,
    8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide
  • Synonyms: Rozerem (TN); 196597-26-9; TAK-375; AC1Q5OQL;Rozerem; AC1L4LKM; Ramelteon [USAN]; CHEMBL1218; S1259_Selleck;N-[2-[(8S)-2,6,7,
    8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide;
  • CAS Registry Number:
  • Melting Point: 113-1150C
  • Density: 1.119g/cm3
  • Refractive index: 1.555
  • Molecular Weight: 259.34344
  • InchiKey: YLXDSYKOBKBWJQ-LBPRGKRZSA-N
  • InChI: InChI=1S/C16H21NO2/c1-2-15(18)17-9-7-12-4-3-11-5-6-14-13(16(11)12)8-10-
    19-14/h5-6,12H,2-4,7-10H2,1H3,(H,17,18)/t12-/m0/s1
  • Molecular Formula: C16H21NO2
  • Molecular Structure:CAS No:196597-26-9 N-[2-[(8S)-2,6,7,<br />8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide

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References of N-[2-[(8S)-2,6,7,
8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide
Title: Ramelteon
CAS Registry Number: 196597-26-9
CAS Name: N-[2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide
Manufacturers' Codes: TAK-375
Trademarks: Rozerem (Takeda)
Molecular Formula: C16H21NO2
Molecular Weight: 259.34
Percent Composition: C 74.10%, H 8.16%, N 5.40%, O 12.34%
Literature References: Melatonin MT1/MT2 receptor agonist. Prepn: S. Ohkawa et al., WO 9732871; eidem US 6034239 (1997, 2000 both to Takeda); O. Uchikawa et al., J. Med. Chem. 45, 4222 (2002). Pharmacology: N. Yukuhiro et al., Brain Res. 1027, 59 (2004). Receptor binding study: K. Kato et al., Neuropharmacology 48, 301 (2005). Reviews of development and therapeutic potential: C. Cajochen, Curr. Opin. Invest. Drugs 6, 114-121 (2005); N. N. Nguyen et al., Formulary 40, 146-155 (2005).
Properties: Crystals from ethyl acetate, mp 113-115°. [a]D20 -57.8° (c = 1.004 in chloroform).
Melting point: mp 113-115°
Optical Rotation: [a]D20 -57.8° (c = 1.004 in chloroform)
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Melatonin Receptor Agonist.