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CAS No 192329-42-3 , Prinomastat

  • Name: Prinomastat
  • Synonyms: Prinomastat;(S)-2-[(Hydroxyamino)methyl]-5,6-dimethyl-4-(4-pyridin-4-yloxyphenyl)sulfonylmorpholine-3-thione;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.377g/cm3
  • Refractive index: 1.615
  • Flash Point: °C
  • Molecular Weight: 423.51
  • InChI: InChI=1/C18H21N3O5S2/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14/h3-10,16,23H,11-12H2,1-2H3,(H,20,22)/t16-/m0/s1
  • Molecular Formula: C18H21N3O5S2
  • Molecular Structure:CAS No:192329-42-3 Prinomastat

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192329-42-3 3-Thiomorpholinecarboxamide,N-hydroxy-2,2-dimethyl-4-[[4-(4-pyridinyloxy)phenyl]sulfonyl]-, (3S)-

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192329-42-3 (S)-2,2-DIMETHYL-N-HYDROXY-4-[4-(4-PYRIDYLOXY)PHENYLSULFONYL]-1,4-THIAZINANE-3-CARBOXAMIDE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of Prinomastat
Title: Prinomastat
CAS Registry Number: 192329-42-3
CAS Name: (3S)-N-Hydroxy-2,2-dimethyl-4-[[4-(4-pyridinyloxy)phenyl]sulfonyl]-3-thiomorpholinecarboxamide
Synonyms: 3(S)-N-hydroxy-4-((4-((pyrid-4-yl)oxy)benzenesulfonyl)-2,2-dimethyl)tetrahydro-2H-1,4-thiazine-3-carboxamide
Manufacturers' Codes: AG-3340
Molecular Formula: C18H21N3O5S2
Molecular Weight: 423.51
Percent Composition: C 51.05%, H 5.00%, N 9.92%, O 18.89%, S 15.14%
Literature References: Selective matrix metalloproteinase inhibitor with antiangiogenic activity. Prepn: S. E. Zook et al., WO 9720824; S. L. Bender, M. J. Melnick, US 5753653 (1997, 1998 both to Agouron). Pharmacokinetic and antitumor efficacy in rats: O. Santos et al., Clin. Exp. Metastasis 15, 499 (1997). Review of pharmacology: D. R. Shalinsky et al., Ann. N.Y. Acad. Sci. 878, 236-270 (1999); and clinical experiences: R. Scatena, Expert Opin. Invest. Drugs 9, 2159-2165 (2000).
Properties: White powder, mp 149.8°. Also reported as 184-186° with gas evolution. Water soluble.
Melting point: mp 149.8°
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic Adjunct; Antimetastatic Agent; Matrix Metalloproteinase Inhibitor.