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CAS No 191588-94-0 , Plasminogen activator(human tissue-type),103-L-asparagine-117-L-glutamine-296-L-alanine-297-L-alanine-298-L-alanine-299-L-alanine-

  • Name: Plasminogen activator(human tissue-type),103-L-asparagine-117-L-glutamine-296-L-alanine-297-L-alanine-298-L-alanine-299-L-alanine-
  • Synonyms: TNKase; Tenecteplase;TNK-tPA;Metalyse;Plasminogen activator(human tissue-type),103-L-asparagine-117-L-glutamine-296-L-alanine-297-L-alanine-298-L-alanine-299-L-alanine-;
  • CAS Registry Number:
  • Molecular Weight: 0

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References of Plasminogen activator(human tissue-type),103-L-asparagine-117-L-glutamine-296-L-alanine-297-L-alanine-298-L-alanine-299-L-alanine-
Title: Tenecteplase
CAS Registry Number: 191588-94-0
CAS Name: 103-L-Asparagine-117-L-glutamine-296-L-alanine-297-L-alanine-298-L-alanine-299-L-alanineplasminogen activator (human tissue-type)
Synonyms: TNK-tPA
Trademarks: Metalyse (Boehringer, Ing.)
Literature References: Genetically engineered variant of human tissue plasminogen activator (t-PA), q.v.; expressed in Chinese hamster ovary cells. mol wt ~65 kDa. Constructed by oligonucleotide-directed mutagenesis at 3 specific sites. Prepn: W. F. Bennett et al., WO 9324635 (1993 to Genentech); B. A. Keyt et al., Proc. Natl. Acad. Sci. USA 91, 3670 (1994). Pharmacology: C. R. Benedict et al., Circulation 92, 3032 (1995). Clinical pharmacokinetics: N. B. Modi et al., Thromb. Haemostasis 79, 134 (1998). Clinical trial in acute myocardial infarction: ASSENT-2 Investigators, Lancet 354, 716 (1999).
Therap-Cat: Thrombolytic.
Keywords: Thrombolytic.