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CAS No 191114-48-4 , Telithromycin Search by region : China

  • Name: Telithromycin
  • Synonyms: (1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone; (1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone;Telithromycin;KETEK;
  • CAS Registry Number:
  • Melting Point: 176-188 C
  • Density: 1.26 g/cm3
  • Safety Statements: 26-36
  • Hazard Symbols: Xi
  • Molecular Weight: 812.00
  • InChI: InChI=1/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27-,28+,29+,32+,33+,36-,37-,38-,40+,42-,43-/m1/s1
  • Risk Statements: 36/37/38
  • Molecular Formula: C43H65N5O10
  • Molecular Structure:CAS No:191114-48-4 Telithromycin

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References of Telithromycin
Title: Telithromycin
CAS Registry Number: 191114-48-4
CAS Name: 3-De[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribohexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]erythromycin
Manufacturers' Codes: HMR-3647; RU-66647
Trademarks: Ketek (Aventis)
Molecular Formula: C43H65N5O10
Molecular Weight: 812.00
Percent Composition: C 63.60%, H 8.07%, N 8.62%, O 19.70%
Literature References: Semisynthetic macrolide antibiotic of the ketolide class, a group of erythromycin derivatives in which the L-cladinose residue has been replaced by a 3-keto group. Prepn: C. Agouridas et al., EP 680967; eidem, US 5635485 (1995, 1997 both to Roussel Uclaf); A. Denis et al., Bioorg. Med. Chem. Lett. 9, 3075 (1999). In vitro activity vs anaerobic bacteria: L. M. Ednie et al., Antimicrob. Agents Chemother. 41, 2019 (1997); vs gram-positive bacteria: K. Malathum et al., ibid. 43, 930 (1999). Time-kill kinetics: F. J. Boswell et al., J. Antimicrob. Chemother. 41, 149 (1998). HPLC analysis: B. Lingerfelt, W. S. Champney, J. Pharm. Biomed. Anal. 20, 459 (1999). Review of pharmacology and clinical trials: G. Ackermann, A. C. Rodloff, J. Antimicrob. Chemother. 51, 497-511 (2003).
Properties: Crystals from ether, mp 187-188°.
Melting point: mp 187-188°
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Macrolides.