Home > Name List By d > DNA,d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) (9CI)

CAS No 190977-41-4 , DNA,d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) (9CI)

  • Name: DNA,d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) (9CI)
  • Synonyms: Oblimersen sodium [USAN]; Oblimersen sodium;Genasense; Augmerosen; UNII-SH55B0RQ9K; G 3139; G3139;DNA,d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) (9CI); UNII-85J5ZP6YSL;
  • CAS Registry Number:
  • Molecular Weight: 5684.614894
  • InchiKey: MIMNFCVQODTQDP-NDLVEFNKSA-N
  • InChI: InChI=1S/C172H221N62O91P17S17/c1-69-39-225(169(253)213-149(69)237)117-
    21-73(236)92(292-117)44-274-326(257,
    343)320-85-33-129(229-63-191-135-141(181)187-61-189-143(135)229)303-103
    (85)55-285-332(263,
    349)314-79-27-122(221-17-9-113(177)201-165(221)249)295-95(79)47-278-330
    (261,
    347)312-78-26-121(220-16-8-112(176)200-164(220)248)298-98(78)50-280-338
    (269,
    355)322-87-35-131(231-65-193-137-145(231)205-157(183)209-153(137)241)
    305-105(87)57-287-334(265,
    351)316-81-29-124(223-19-11-115(179)203-167(223)251)299-99(81)51-281-339
    (270,
    356)323-88-36-132(232-66-194-138-146(232)206-158(184)210-154(138)242)
    307-107(88)59-289-337(268,
    354)319-84-32-128(228-42-72(4)152(240)216-172(228)256)302-102(84)54-284-
    341(272,
    358)325-90-38-134(234-68-196-140-148(234)208-160(186)212-156(140)244)
    306-106(90)58-288-335(266,
    352)317-82-30-125(224-20-12-116(180)204-168(224)252)300-100(82)52-282-
    340(271,
    357)324-89-37-133(233-67-195-139-147(233)207-159(185)211-155(139)243)
    308-108(89)60-290-342(273,
    359)321-86-34-130(230-64-192-136-142(182)188-62-190-144(136)230)304-104
    (86)56-286-333(264,
    350)315-80-28-123(222-18-10-114(178)202-166(222)250)296-96(80)48-277-328
    (259,
    345)310-76-24-119(218-14-6-110(174)198-162(218)246)294-94(76)46-276-329
    (260,
    346)311-77-25-120(219-15-7-111(175)199-163(219)247)297-97(77)49-279-336
    (267,
    353)318-83-31-127(227-41-71(3)151(239)215-171(227)255)301-101(83)53-283-
    331(262,
    348)313-75-23-118(217-13-5-109(173)197-161(217)245)293-93(75)45-275-327
    (258,
    344)309-74-22-126(291-91(74)43-235)226-40-70(2)150(238)214-170(226)254/
    h5-20,39-42,61-68,73-108,117-134,235-236H,21-38,43-60H2,1-4H3,(H,257,
    343)(H,258,344)(H,259,345)(H,260,346)(H,261,347)(H,262,348)(H,263,
    349)(H,264,350)(H,265,351)(H,266,352)(H,267,353)(H,268,354)(H,269,
    355)(H,270,356)(H,271,357)(H,272,358)(H,273,359)(H2,173,197,245)(H2,174,
    198,246)(H2,175,199,247)(H2,176,200,248)(H2,177,201,249)(H2,178,202,
    250)(H2,179,203,251)(H2,180,204,252)(H2,181,187,189)(H2,182,188,190)(H,
    213,237,253)(H,214,238,254)(H,215,239,255)(H,216,240,256)(H3,183,205,
    209,241)(H3,184,206,210,242)(H3,185,207,211,243)(H3,186,208,212,
    244)/t73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,
    89-,90-,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,
    105+,106+,107+,108+,117+,118+,119+,120+,121+,122+,123+,124+,125+,126+,
    127+,128+,129+,130+,131+,132+,133+,134+,326?,327?,328?,329?,330?,331?,
    332?,333?,334?,335?,336?,337?,338?,339?,340?,341?,342?/m0/s1
  • Molecular Formula: C172H221N62O91P17S17
  • Molecular Structure:CAS No:190977-41-4 DNA,d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) (9CI)

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190977-41-4 Oblimersen

  • Oblimersen, Min 99%
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190977-41-4 OBLIMERSEN SODIUM

  • OBLIMERSEN SODIUM
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References of DNA,d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) (9CI)
Title: Oblimersen Sodium
CAS Registry Number: 190977-41-4
CAS Name: d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T)DNA
Synonyms: augmerosen
Manufacturers' Codes: G-3139
Trademarks: Genasense (Genta)
Literature References: Synthetic 18 base phosphorothioate antisense oligonucleotide (AS ON); designed to bind to human bcl-2 oncogene, resulting in the down-regulation of an apoptosis-inhibiting protein Bcl-2. Prepn: J. C. Reed, WO 9508350 (1995); idem, US 5831066 (1998 to Univ. of Penn.). LC/MS determn in plasma and urine: G. Dai et al., J. Chromatogr. B 825, 201 (2005). Pharmacokinetics: F. I. Raynaud et al., J. Pharmacol. Exp. Ther. 281, 420 (1997). Mechanism of action study: L. Benimetskaya et al., Oligonucleotides 15, 206 (2005). Clinical evaluations in malignant melanoma: B. Jansen et al., Lancet 356, 1728 (2000); in non-Hodgkin's lymphoma: J. S. Waters et al., J. Clin. Oncol. 18, 1812 (2000); in prostate cancer: K. N. Chi et al., Clin. Cancer Res. 7, 3920 (2001). Review of pharmacology, preclinical and clinical development: R. J. Klasa et al., Antisense Nucleic Acid Drug Dev. 12, 193-213 (2002). Review of therapeutic potential in lung cancer: R. S. Herbst, S. R. Frankel, Clin. Cancer Res. 10, 4245s-4248s (2004); in prostate cancer: K. N. Chi, World J. Urol. 23, 33-37 (2005).
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Oligonucleotides.