Home > Name List By other > [(2R,3R,4R,5S,6R)-4-decoxy-5-hydroxy-6-[[(2R,3R,4R,5S, 6R)-4-[(3R)-3-methoxydecoxy]-6-(methoxymethyl)-3-[[(Z)-octadec-11-enoy...

CAS No 185955-34-4 , [(2R,3R,4R,5S,6R)-4-decoxy-5-hydroxy-6-[[(2R,3R,4R,5S,
6R)-4-[(3R)-3-methoxydecoxy]-6-(methoxymethyl)-3-[[(Z)-octadec-11-enoyl]
amino]-5-phosphonooxyoxan-2-yl]oxymethyl]-3-(3-oxotetradecanoylamino)
oxan-2-yl] dihydrogen phosphate

  • Name: [(2R,3R,4R,5S,6R)-4-decoxy-5-hydroxy-6-[[(2R,3R,4R,5S,
    6R)-4-[(3R)-3-methoxydecoxy]-6-(methoxymethyl)-3-[[(Z)-octadec-11-enoyl]
    amino]-5-phosphonooxyoxan-2-yl]oxymethyl]-3-(3-oxotetradecanoylamino)
    oxan-2-yl] dihydrogen phosphate
  • Synonyms: 185955-34-4;[(2R,3R,4R,5S,6R)-4-decoxy-5-hydroxy-6-[[(2R,3R,4R,5S,
    6R)-4-[(3R)-3-methoxydecoxy]-6-(methoxymethyl)-3-[[(Z)-octadec-11-enoyl]
    amino]-5-phosphonooxyoxan-2-yl]oxymethyl]-3-(3-oxotetradecanoylamino)
    oxan-2-yl] dihydrogen phosphate; Eritoran [INN]; CHEBI:68609; UNII-551541VI0Y; AC1OC63J; CHEBI:614906; CHEMBL501259; CHEBI:49576; DNC009286;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.14
  • Flash Point: °C
  • Molecular Weight: 1313.656164
  • InchiKey: BPSMYQFMCXXNPC-MFCPCZTFSA-N
  • InChI: InChI=1S/C66H126N2O19P2/c1-7-11-15-19-22-25-26-27-28-29-30-32-34-38-42-
    46-57(70)67-60-64(82-49-47-54(80-6)45-41-36-18-14-10-4)62(86-88(73,
    74)75)56(51-79-5)85-65(60)83-52-55-61(72)63(81-48-43-39-35-24-21-17-13-
    9-3)59(66(84-55)87-89(76,
    77)78)68-58(71)50-53(69)44-40-37-33-31-23-20-16-12-8-2/h25-26,54-56,
    59-66,72H,7-24,27-52H2,1-6H3,(H,67,70)(H,68,71)(H2,73,74,75)(H2,76,77,
    78)/b26-25-/t54-,55-,56-,59-,60-,61-,62-,63-,64-,65-,66-/m1/s1
  • Molecular Formula: C66H126N2O19P2
  • Molecular Structure:CAS No:185955-34-4 [(2R,3R,4R,5S,6R)-4-decoxy-5-hydroxy-6-[[(2R,3R,4R,5S,<br />6R)-4-[(3R)-3-methoxydecoxy]-6-(methoxymethyl)-3-[[(Z)-octadec-11-enoyl]<br />amino]-5-phosphonooxyoxan-2-yl]oxymethyl]-3-(3-oxotetradecanoylamino)<br />oxan-2-yl] dihydrogen phosphate

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185955-34-4 ERITORAN

  • China HANGZHOU ONICON CHEMICAL CO.,LTD [Manufacturer]
  • Tel: +86-571-85054016/ +86-571-85104679
  • Fax: +86-571-85054082
  • Address: HANGZHOU ONICON CHEMICAL CO.,LTD
    303-306 Hangzhou yiyao Building,
    No.439 Zhongshan North Rd.
    Hangzhou China
    Phone : +86-571-85054016
    Fax: +86-571-85054082
    E-Mail1: cjw9999@163.com null,nullChina
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185955-34-4 ERITORAN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
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References of [(2R,3R,4R,5S,6R)-4-decoxy-5-hydroxy-6-[[(2R,3R,4R,5S,
6R)-4-[(3R)-3-methoxydecoxy]-6-(methoxymethyl)-3-[[(Z)-octadec-11-enoyl]
amino]-5-phosphonooxyoxan-2-yl]oxymethyl]-3-(3-oxotetradecanoylamino)
oxan-2-yl] dihydrogen phosphate
Title: Eritoran
CAS Registry Number: 185955-34-4
CAS Name: 3-O-Decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-b-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-a-D-glucopyranose 1-(dihydrogen phosphate)
Molecular Formula: C66H126N2O19P2
Molecular Weight: 1313.66
Percent Composition: C 60.34%, H 9.67%, N 2.13%, O 23.14%, P 4.72%
Literature References: Toll-like receptor 4 (TLR4) antagonist. Synthetic analog of the lipid A component of endotoxin, a major constituent of the outer membrane of Gram negative bacteria. Prepn: W. J. Christ et al., WO 9639411; eidem, US 5750664 (1996, 1998 both to Eisai). Pharmacology: M. Mullarkey et al., J. Pharmacol. Exp. Ther. 304, 1093 (2003). Clinical pharmacokinetics: Y. N. Wong et al., J. Clin. Pharmacol. 43, 735 (2003); and lipid distribution profile: D. P. Rossignol et al., Antimicrob. Agents Chemother. 48, 3233 (2004). Clinical evaluation in experimental endotoxemia: M. Lynn et al., J. Pharmacol. Exp. Ther. 308, 175 (2004). Review of pharmacology and clinical experience: D. P. Rossignol, M. Lynn, Curr. Opin. Invest. Drugs 6, 496-502 (2005).
 
Derivative Type: Tetrasodium salt
CAS Registry Number: 185954-98-7
Manufacturers' Codes: E-5564; B-1287
Molecular Formula: C66H122N2Na4O19P2
Molecular Weight: 1401.58
Percent Composition: C 56.56%, H 8.77%, N 2.00%, Na 6.56%, O 21.69%, P 4.42%
 
Therap-Cat: In treatment of severe sepsis.
Keywords: Antisepsis.