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CAS No 182815-44-7 , 2-(chloromethyl)oxirane

  • Name: 2-(chloromethyl)oxirane
  • Synonyms:
    trimethyl-[6-(prop-2-enylamino)hexyl]azanium;N-prop-2-enyldecan-1-amine;Colesevelam hydrochloride;prop-2-en-1-amine; Welchol;hydrochloride;chloride; GT 31-104HB; 182815-44-7; CholestaGel;2-(chloromethyl)oxirane; GT 31-104;
  • CAS Registry Number:
  • Flash Point: °Cat760mmHg
  • Boiling Point: °Cat760mmHg
  • Density: g/cm3
  • Flash Point: °Cat760mmHg
  • Molecular Weight: 618.24888
  • InchiKey: VTAKZNRDSPNOAU-UHFFFAOYSA-M
  • InChI: InChI=1S/C13H27N.C12H27N2.C3H5ClO.C3H7N.2ClH/c1-3-5-6-7-8-9-10-11-13-14-
    12-4-2;1-5-10-13-11-8-6-7-9-12-14(2,3)4;4-1-3-2-5-3;1-2-3-4;;/h4,14H,
    2-3,5-13H2,1H3;5,13H,1,6-12H2,2-4H3;3H,1-2H2;2H,1,
    3-4H2;2*1H/q;+1;;;;/p-1
  • Molecular Formula: C31H67Cl3N4O
  • Molecular Structure:CAS No:182815-44-7 2-(chloromethyl)oxirane

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182815-44-7 Colesevelam

  • United States LGM Pharma [Manufacturer]
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182815-44-7 COLESEVELAM

  • United States ACIC [Manufacturer]
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182815-44-7 COLESEVELAM

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  • Tel: 800-222-0921/ 973-473-4300
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182815-44-7 COLESEVELAM HCL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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References of 2-(chloromethyl)oxirane
Title: Colesevelam Hydrochloride
CAS Registry Number: 182815-44-7
CAS Name: N,N,N-Trimethyl-6-(2-propenylamino)-1-hexanaminium chloride polymer with (chloromethyl)oxirane, 2-propen-1-amine and N-2-propenyl-1-decanamine, hydrochloride
Manufacturers' Codes: GT-31-104
Trademarks: CholestaGel (GelTex); Welchol (Sankyo)
Literature References: Bile acid sequestrant composed of a polyallylamine cross-linked with epichlorohydrin and alkylated with 1-bromodecane and 6-bromohexyltrimethylammonium bromide. Prepn: H. W. Mandeville, III, S. R. Holmes-Farley, WO 9534585; eidem, US 5693675 (1995, 1997 both to GelTex); and bile acid binding: W. H. Mandeville et al., Mater. Res. Soc. Symp. Proc. 550, 3 (1999). Absorption, distribution and excretion: D. P. Rosenbaum et al., J. Pharm. Sci. 86, 591 (1997). Clinical trial in hypercholesterolemia: W. Insull, Jr. et al., Mayo Clin. Proc. 76, 971 (2001). Review of pharmacology and clinical experience: M. A. Aldridge, M. K. Ito, Ann. Pharmacother. 35, 898-907 (2001).
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Bile Acid Sequesterants.