Home > Name List By other > [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl] amino]butyl]boronic acid China

CAS No 179324-69-7 , [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]
amino]butyl]boronic acid Search by region : China

  • Name: [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]
    amino]butyl]boronic acid
  • Synonyms: LDP-341; 179324-69-7; CHEBI:52717; NSC-681239;[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]
    amino]butyl]boronic acid;PS-341; Velcade; DPBA; MG-341; Ps 341;
  • CAS Registry Number:
  • Density: 1.214
  • Refractive index: 1.564
  • Molecular Weight: 384.2372
  • InchiKey: GXJABQQUPOEUTA-RDJZCZTQSA-N
  • InChI: InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-
    14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,
    23,26)(H,24,25)/t15-,17-/m0/s1
  • Molecular Formula: C19H25BN4O4
  • Molecular Structure:CAS No:179324-69-7 [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]<br />amino]butyl]boronic acid

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References of [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]
amino]butyl]boronic acid
Title: Bortezomib
CAS Registry Number: 179324-69-7
CAS Name: [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Synonyms: N-(2-pyrazine)carbonyl-L-phenylalanine-L-leucine boronic acid
Manufacturers' Codes: MG-341; PS-341
Trademarks: Velcade (Millenium)
Molecular Formula: C19H25BN4O4
Molecular Weight: 384.24
Percent Composition: C 59.39%, H 6.56%, B 2.81%, N 14.58%, O 16.66%
Literature References: Dipeptide boronic acid proteasome inhibitor. Prepn: J. Adams et al., WO 9613266; eidem, US 5780454 (1996, 1998 both to ProScript); idem et al., Bioorg. Med. Chem. Lett. 8, 333 (1998). Pharmacology and cytotoxic activity: idem et al., Cancer Res. 59, 2615 (1999). Crystal structure in complex with the yeast 20S proteasome: M. Groll et al., Structure 14, 451 (2006). Mechanism of action study: J. Codony-Servat et al., Mol. Cancer Ther. 5, 665 (2006). Clinical trial in refractory myeloma: P. G. Richardson et al., N. Engl. J. Med. 348, 2609 (2003). Review of clinical development: idem et al., Annu. Rev. Med. 57, 33-47 (2006).
Properties: Soly in water: 3.3-3.8 mg/ml (pH 2-6.5).
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic.