Home > Name List By 1 > 1H-Imidazole-2-methanol,5-[(3,5-dichlorophenyl)thio]-4-(1-methylethyl)-1-(4-pyridinylmethyl)-,2-carbamate

CAS No 178979-85-6 , 1H-Imidazole-2-methanol,5-[(3,5-dichlorophenyl)thio]-4-(1-methylethyl)-1-(4-pyridinylmethyl)-,2-carbamate

  • Name: 1H-Imidazole-2-methanol,5-[(3,5-dichlorophenyl)thio]-4-(1-methylethyl)-1-(4-pyridinylmethyl)-,2-carbamate
  • Synonyms: 1H-Imidazole-2-methanol,5-[(3,5-dichlorophenyl)thio]-4-(1-methylethyl)-1-(4-pyridinylmethyl)-,2-carbamate; AGI 549; Capravirine; S 1153; AG 1549;1H-Imidazole-2-methanol,5-[(3,5-dichlorophenyl)thio]-4-(1-methylethyl)-1-(4-pyridinylmethyl)-,carbamate (ester) (9CI);
  • CAS Registry Number:
  • Flash Point: 344.5°C
  • Boiling Point: 646°Cat760mmHg
  • Density: 1.4g/cm3
  • Refractive index: 1.656
  • Flash Point: 344.5°C
  • Molecular Weight: 0
  • InChI: InChI=1/C20H20Cl2N4O2S/c1-12(2)18-19(29-16-8-14(21)7-15(22)9-16)26(10-13-3-5-24-6-4-13)17(25-18)11-28-20(23)27/h3-9,12H,10-11H2,1-2H3,(H2,23,27)
  • Molecular Formula: C20H20 Cl2 N4 O2 S
  • Molecular Structure:CAS No:178979-85-6 1H-Imidazole-2-methanol,5-[(3,5-dichlorophenyl)thio]-4-(1-methylethyl)-1-(4-pyridinylmethyl)-,2-carbamate

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178979-85-6 Capravirine

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References of 1H-Imidazole-2-methanol,5-[(3,5-dichlorophenyl)thio]-4-(1-methylethyl)-1-(4-pyridinylmethyl)-,2-carbamate
Title: Capravirine
CAS Registry Number: 178979-85-6
CAS Name: 5-[(3,5-Dichlorophenyl)thio]-4-(1-methylethyl)-1-(4-pyridinylmethyl)-1H-imidazole-2-methanol carbamate ester
Synonyms: 2-carbamoyloxymethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-1-(pyridin-4-yl)methyl-1H-imidazole
Manufacturers' Codes: AG-1549; S-1153
Molecular Formula: C20H20Cl2N4O2S
Molecular Weight: 451.37
Percent Composition: C 53.22%, H 4.47%, Cl 15.71%, N 12.41%, O 7.09%, S 7.10%
Literature References: Imidazole type non-nucleoside HIV-1 reverse transcriptase inhibitor (NNRTI). Prepn: H. Sugimoto, T. Fujiwara, WO 9610019; eidem, US 5910506 (1996, 1999 both to Shionogi). Antiviral activity: T. Fujiwara et al., Antimicrob. Agents Chemother. 42, 1340 (1998). Crystal structure in complex with target enzyme: J. Ren et al., J. Biol. Chem. 275, 14316 (2000). Review of pharmacology and clinical evaluation: W. M. Brown, Curr. Opin. Anti-Infect. Invest. Drugs 2, 286-294 (2000).
Properties: Crystals from diethylether as hemihydrate, mp 88° (dec).
Melting point: mp 88° (dec)
Therap-Cat: Antiviral
Keywords: Antiviral; Reverse Transcriptase Inhibitor.