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CAS No 175463-14-6 , gemifioxacin Search by region : China

  • Name: gemifioxacin
  • Synonyms: 7-(3-aminomethyl)-4-methoxyimino-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydro-[1, 8]naphthyridine-3-carboxylic acid; 7-[3-(Aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Mesilate;gemifioxacin;
  • CAS Registry Number:
  • Density: 1.64g/cm3
  • Refractive index: 1.735
  • Molecular Weight: 389.39
  • InChI: InChI=1/C18H20FN5O4/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27)/b22-14+
  • Molecular Formula: C18H20FN5O4
  • Molecular Structure:CAS No:175463-14-6 gemifioxacin

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References of gemifioxacin
Title: Gemifloxacin
CAS Registry Number: 175463-14-6
CAS Name: 7-[3-(Aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
Manufacturers' Codes: SB-265805; LB-20304
Molecular Formula: C18H20FN5O4
Molecular Weight: 389.38
Percent Composition: C 55.52%, H 5.18%, F 4.88%, N 17.99%, O 16.44%
Literature References: Third generation fluorinated quinolone antibacterial. Prepn: J. H. Kwak et al., EP 688772; C. Y. Hong et al., US 5633262 (1995, 1997 both to LG Chemical); C. Y. Hong et al., J. Med. Chem. 40, 3584 (1997). Antibacterial spectrum in vitro: R. Wise, J. M. Andrews, J. Antimicrob. Chemother. 44, 679 (1999). HPLC-tandem MS determn in human plasma: E. Doyle et al., J. Chromatogr. B 746, 191 (2000). Clinical pharmacokinetics: A. Allen et al., Antimicrob. Agents Chemother. 44, 1604 (2000). Review of antibacterial activity, pharmacology, and clinical trials: J. M. Blondeau, B. Missaghi, Expert Opin. Pharmacother. 5, 1117-1152 (2004).
Properties: Off-white, amorphous solid from chloroform-ethanol, mp 235-237°.
Melting point: mp 235-237°
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.