Home > Name List By 1 > 1H-1,4-Benzodiazepine-2-aceticacid, 7-([4,4'-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-,(2S)-

CAS No 171049-14-2 , 1H-1,4-Benzodiazepine-2-aceticacid, 7-([4,4'-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-,(2S)-

  • Name: 1H-1,4-Benzodiazepine-2-aceticacid, 7-([4,4'-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-,(2S)-
  • Synonyms: Lotrafiban;(2S)-7-[(4,4'-Bipiperidin)-1-ylcarbonyl]-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-aceticacid;1H-1,4-Benzodiazepine-2-aceticacid, 7-([4,4'-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-,(S)-; SB 214857;1H-1,4-Benzodiazepine-2-aceticacid, 7-([4,4'-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-,(2S)-;
  • CAS Registry Number:
  • Flash Point: 395.3°C
  • Boiling Point: 730°C at 760 mmHg
  • Density: 1.22g/cm3
  • Refractive index: 1.572
  • Flash Point: 395.3°C
  • Molecular Weight: 428.5246
  • InChI: InChI=1/C23H32N4O4/c1-26-14-18-12-17(2-3-19(18)25-20(23(26)31)13-21(28)29)22(30)27-10-6-16(7-11-27)15-4-8-24-9-5-15/h2-3,12,15-16,20,24-25H,4-11,13-14H2,1H3,(H,28,29)/t20-/m0/s1
  • Molecular Formula: C23H32 N4 O4
  • Molecular Structure:CAS No:171049-14-2 1H-1,4-Benzodiazepine-2-aceticacid, 7-([4,4'-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-,(2S)-

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171049-14-2 1H-1,4-Benzodiazepine-2-aceticacid, 7-([4,4'-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-,(2S)-

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171049-14-2 (2S)-7-(4,4''-BIPIPERIDIN-1-YLCARBONYL)-4-METHYL-3-OXO-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-2-YL]ACETIC ACID

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References of 1H-1,4-Benzodiazepine-2-aceticacid, 7-([4,4'-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-,(2S)-
Title: Lotrafiban
CAS Registry Number: 171049-14-2
CAS Name: (2S)-7-([4,4￠-Bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid
Manufacturers' Codes: SB-214857
Molecular Formula: C23H32N4O4
Molecular Weight: 428.52
Percent Composition: C 64.47%, H 7.53%, N 13.07%, O 14.93%
Literature References: Specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. Prepn: W. E. Bondinell et al., WO 9518619; W. E. Bondinell, J. M. Samanen, US 6117866 (1995, 2000 both to SmithKline Beecham). Enantiospecific synthesis: W. H. Miller et al., Tetrahedron Lett. 36, 9433 (1995). Structure-activity study: J. M. Samanen et al., J. Med. Chem. 39, 4867 (1996). Binding study: A. Wong et al., J. Pharmacol. Exp. Ther. 285, 228 (1998). Clinical evaluation in patients with coronary or cerebral atherosclerosis: R. A. Harrington et al., Circulation 102 728 (2000). Clinical trial in cerebrovascular and coronary artery disease: E. J. Topol et al., Circulation 108, 399 (2003).
Properties: Zwitterionic. [a]D -200.1° (c = 0.5 in methanol).
Optical Rotation: [a]D -200.1° (c = 0.5 in methanol)
Therap-Cat: Antithrombotic.
Keywords: Fibrinogen Receptor Antagonist; Antithrombotic.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.