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CAS No 17090-79-8 , Monensin Search by region : China

  • Name: Monensin
  • Synonyms: 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-beta-methoxy-alpha,gamma,2,8-tetramethyl-1,6-dioxaspiro[4.5]decane-7-butyric acid;Monensin;
  • CAS Registry Number:
  • Transport: UN 3462
  • Density: 1.21 g/cm3
  • Safety Statements: Poison by ingestion and intraperitoneal routes. An eye and skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Hazard Symbols: T: Toxic;
  • EINECS: 241-154-0
  • Molecular Weight: 670.88
  • InChI: InChI=1/C37H64O10.Na/c1-11-35(32-21(4)18-27(43-32)29-20(3)17-22(5)37(41,12-2)46-29)14-13-28(44-35)34(9)15-16-36(47-34)19-26(38)23(6)31(45-36)24(7)30(42-10)25(8)33(39)40;/h20-32,38,41H,11-19H2,1-10H3,(H,39,40);/q;+1/p-1/t20-,21-,22+,23+,24+,25-,26-,27+,28+,29?,30+,31-,32?,34-,35-,36?,37-;/m0./s1
  • Risk Statements: 25
  • Molecular Formula: C36H62O11
  • Molecular Structure:CAS No:17090-79-8 Monensin

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17090-79-8 MONENSIN

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  • China Maple Chemical Co.,ltd. [Manufacturer]
  • Tel: 86-574- 87512300
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  • Address: No.347,Sanbei Road,Sanbei Town,Cixi ,Zhejiang,China Ningbo,ZhejiangChina
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  • China Taizhou Creating Chemical Co.,Ltd [Manufacturer]
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17090-79-8 Monensin

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References of Monensin
Title: Monensin
CAS Registry Number: 17090-79-8
CAS Name: 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-b-methoxy-a,g,2,8-tetramethyl-1,6-dioxaspiro[4.5]decane-7-butyric acid
Synonyms: monensic acid (obsolete)
Manufacturers' Codes: A-3823A
Molecular Formula: C36H62O11
Molecular Weight: 670.87
Percent Composition: C 64.45%, H 9.32%, O 26.23%
Literature References: Polyether antibiotic. Major factor in antibiotic complex isolated from Streptomyces cinnamonensis. Discovery and isolation: Haney, Hoehn, Antimicrob. Agents Chemother. 1967, 349. Production: Haney, Hoehn, US 3501568 (1970 to Lilly). Structure: Agtarap et al., J. Am. Chem. Soc. 89, 5737 (1967). Crystal structure studies: Lutz et al., Helv. Chim. Acta 53, 1732 (1970); ibid. 54, 1103 (1971). Fermentation studies: Stark et al., Antimicrob. Agents Chemother. 1967, 353. Chemistry: Agtarap, Chamberlin, ibid. 359. Stereocontrolled total synthesis: T. Fukuyama et al., J. Am. Chem. Soc. 101, 262 (1979); D. B. Collum et al., ibid. 102, 2117, 2118, 2120 (1980). 13C-NMR study: J. A. Robinson, D. L. Turner, Chem. Commun. 1982, 148. Biosynthesis: Day et al., Antimicrob. Agents Chemother. 4, 410 (1973). Review: Stark, "Monensin, A New Biologically Active Compound Produced by a Fermentation Process", in Fermentation Advances, Pap. Int. Ferment. Symp., 3rd, 1968, D. Perlman, Ed. (Academic Press, New York, 1969) pp 517-540.
Properties: Crystals, mp 103-105° (monohydrate). [a]D +47.7°. pKa 6.6 (in 66% DMF). Very stable under alkaline conditions. Slightly sol in water; more sol in hydrocarbons; very sol in other organic solvents. LD50 of monensin complex in mice, chicks (mg/kg): 43.8 ± 5.2, 284 ± 47 orally (Haney, Hoehn).
Melting point: mp 103-105° (monohydrate)
pKa: pKa 6.6 (in 66% DMF)
Optical Rotation: [a]D +47.7°
Toxicity data: LD50 of monensin complex in mice, chicks (mg/kg): 43.8 ± 5.2, 284 ± 47 orally (Haney, Hoehn)
 
Derivative Type: Sodium salt
Trademarks: Coban (Elanco); Romensin (Elanco); Rumensin (Elanco)
Molecular Formula: C36H61NaO11
Molecular Weight: 692.85
Percent Composition: C 62.41%, H 8.87%, Na 3.32%, O 25.40%
Properties: mp 267-269°. [a]D +57.3° (methanol). Slightly sol in water; more sol in hydrocarbons; very sol in other organic solvents.
Melting point: mp 267-269°
Optical Rotation: [a]D +57.3° (methanol)
 
Therap-Cat-Vet: Coccidiostat. Feed additive to improve feed efficiency in ruminants.