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CAS No 163706-06-7 , CANGRELOR

  • Name: CANGRELOR
  • Synonyms: CANGRELOR;
  • CAS Registry Number:
  • Flash Point: 545.882°C
  • Boiling Point: 979.004°C at 760 mmHg
  • Density: 2.087g/cm3
  • Refractive index: 1.722
  • Flash Point: 545.882°C
  • Molecular Weight: 776.362
  • InChI: InChI=1/C17H25Cl2F3N5O12P3S2/c1-43-5-3-23-12-9-13(26-15(25-12)44-4-2-16(20,21)22)27(7-24-9)14-11(29)10(28)8(38-14)6-37-42(35,36)39-41(33,34)17(18,19)40(30,31)32/h7-8,10-11,14,28-29H,2-6H2,1H3,(H,33,34)(H,35,36)(H,23,25,26)(H2,30,31,32)/t8-,10-,11-,14-/m1/s1
  • Molecular Formula: C17H25Cl2F3N5O12P3S2
  • Molecular Structure:CAS No:163706-06-7 CANGRELOR

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163706-06-7 Cangrelor

  • Cangrelor, an adenylic acid derivative, has been found to be a P2Y12 inhibitor that could be effective in some coronary artery diseases. It is approved by FDA as an antiplatelet drug. It has been used to reduce the risk of heart attack during cardiol...
  • Min. Order: 10
  • United States BOC Sciences [Manufacturer]
  • Tel: 1-631-4854226
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References of CANGRELOR
Title: Cangrelor
CAS Registry Number: 163706-06-7
CAS Name: N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-5￠-adenylic acid monoanhydride with (dichloromethylene)bis[phosphonic acid]
Synonyms: N6-(2-methylthioethyl)-2-(3,3,3-trifluoropropylthio)-b,g-dichloromethylene ATP
Manufacturers' Codes: AR-C69931XX
Molecular Formula: C17H25Cl2F3N5O12P3S2
Molecular Weight: 776.36
Percent Composition: C 26.30%, H 3.25%, Cl 9.13%, F 7.34%, N 9.02%, O 24.73%, P 11.97%, S 8.26%
Literature References: Specific P2Y12 purinoceptor antagonist; inhibits ADP-induced platelet aggregation. Prepn: A. H. Ingall et al., WO 9418216 (1994 to Fisons); eidem, US 5721219 (1998 to Astra); and in vivo antithrombotic activity: idem et al., J. Med. Chem. 42, 213 (1999). In vivo antithrombotic effects in canine arterial thrombosis: J. Huang et al., J. Pharmacol. Exp. Ther. 295, 492 (2000). Mechanism of action study: A. Ishii-Watabe et al., Biochem. Pharmacol. 59, 1345 (2000). Clinical safety assessment and evaluation in acute coronary syndromes: R. F. Storey et al., Thromb. Haemostasis 85, 401 (2001); in angina pectoris and non-Q-wave myocardial infarction: F. Jacobsson et al., Clin. Ther. 24, 752 (2002). Clinical pharmacodynamics compared with clopidogrel: R. F. Storey et al., Platelets 13, 407 (2002). Review of clinical development: S. C. Chattaraj, Curr. Opin. Invest. Drugs 2, 250-255 (2001).
 
Derivative Type: Tetrasodium salt
CAS Registry Number: 163706-36-3
Manufacturers' Codes: AR-C69931MX
Molecular Formula: C17H21Cl2F3N5Na4O12P3S2
Molecular Weight: 864.29
Percent Composition: C 23.62%, H 2.45%, Cl 8.20%, F 6.59%, N 8.10%, Na 10.64%, O 22.21%, P 10.75%, S 7.42%
Properties: Freely sol in water.
 
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic.