Title: Palifermin
CAS Registry Number: 162394-19-6
CAS Name: 24-163-Keratinocyte growth factor (human)
Synonyms: 24-163-fibroblast growth factor 7 (human); rHuKGF
Trademarks: Kepivance (Amgen)
Literature References: Recombinant epithelial tissue growth factor of 141 amino acid residues; N-terminal truncated form of endogenous KGF. Mol wt approx 16.3 kDa. Prepn: D. J. Gospodarowicz, F. R. Masiarz,
WO 9501434;
eidem, US 5677278 (1995, 1997 both to Chiron).
In vivo radioprotective effect: C. L. Farrell
et al., Cancer Res. 58, 933 (1998). Clinical study in mucositis associated with myelosuppressive therapy: R. Spielberger
et al., N. Engl. J. Med. 351, 2590 (2004). Review of therapeutic potential in oral mucositis: M. A. A. Siddiqui, K. Wellington,
Drugs 65, 2139-2146 (2005); M. L. Radtke, J. M. Kolesar,
J. Oncol. Pharm. Pract. 11, 121-125 (2005).
Therap-Cat: Radioprotective agent.
Keywords: Antineoplastic Adjunct; Radioprotective.
