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CAS No 152811-62-6 , 2H-[1,3]Oxazino[3,2-a]indole-10-carboxamide,N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-

  • Name: 2H-[1,3]Oxazino[3,2-a]indole-10-carboxamide,N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-
  • Synonyms: 2H-[1,3]Oxazino[3,2-a]indole-10-carboxamide,N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-;Piboserod;SB 207266;
  • CAS Registry Number:
  • Flash Point: 298.7°C
  • Boiling Point: 570.3°C at 760 mmHg
  • Density: 1.22g/cm3
  • Refractive index: 1.625
  • Flash Point: 298.7°C
  • Molecular Weight: 0
  • InChI: InChI=1/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26)
  • Molecular Formula: C22H31 N3 O2
  • Molecular Structure:CAS No:152811-62-6 2H-[1,3]Oxazino[3,2-a]indole-10-carboxamide,N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-

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References of 2H-[1,3]Oxazino[3,2-a]indole-10-carboxamide,N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-
Title: Piboserod
CAS Registry Number: 152811-62-6
CAS Name: N-[(1-Butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide
Manufacturers' Codes: SB-207266
Molecular Formula: C22H31N3O2
Molecular Weight: 369.50
Percent Composition: C 71.51%, H 8.46%, N 11.37%, O 8.66%
Literature References: Selective 5-HT4 receptor antagonist. Prepn: L. M. Gaster, P. A. Wyman, WO 9318036; eidem, US 5852014 (1993, 1998 both to SKB). In vitro and in vivo studies of bioavailability, pharmacokinetics, and duration: K. A. Wardle et al., Br. J. Pharmacol. 118, 665 (1996). Effect on gastrointestinal function: G. J. Sanger et al., Neurogastroenterol. Motil. 10, 271 (1998); idem et al., Br. J. Pharmacol. 130, 706 (2000). Clinical evaluation in irritable bowel syndrome: L. A. Houghton et al., Aliment. Pharmacol. Ther. 13, 1437 (1999).
Properties: White solid from ether, mp 110-113°.
Melting point: mp 110-113°
 
Derivative Type: Hydrochloride
CAS Registry Number: 178273-87-5
Manufacturers' Codes: SB-207266A
Molecular Formula: C22H31N3O2.HCl
Molecular Weight: 405.96
Percent Composition: C 65.09%, H 7.95%, N 10.35%, O 7.88%, Cl 8.73%
Properties: White crystals from ETOH/petrol, mp 254-256° (dec).
Melting point: mp 254-256°
 
Therap-Cat: Gastroprokinetic
Keywords: Gastroprokinetic; Serotonin Receptor Antagonist.