CAS No 14918-35-5 , D-Streptamine,O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1®

Name: D-Streptamine,O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1®
Synonyms: 5)-2-deoxy-N1-methyl-;DestomycinA (7CI,8CI); Destonate 20;2-3)-O-b-D-talopyranosyl-(1®D-Streptamine,O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1® Spiro[4H-1,3-dioxolo[4,5-c]pyran-2,2'-[2H]pyran], D-streptaminederiv.; NSC 96877;
CAS Registry Number:14918-35-5
Flash Point: 496.7°C
Boiling Point: 897.6°Cat760mmHg
Density: 1.67g/cm³
Refractive index: 1.672
Safety Statements: Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NO_x.
Flash Point: 496.7°C
Molecular Weight: 527.60
InChI: InChI=1/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6?,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20-/m1/s1
Molecular Formula: C20H37 N3 O13
Molecular Structure:

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References of D-Streptamine,O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1®

Title: Destomycin A
CAS Registry Number: 14918-35-5
CAS Name: O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1?2-3)-O-b-D-talopyranosyl-(1?5)-2-deoxy-N￠-methyl-D-streptamine
Synonyms: 5-O-[2,3-O-[6-(1-amino-2-hydroxyethyl)tetrahydro-3,4,5-trihydroxy-2H-pyran-2-ylidene]-b-D-talopyranosyl]-2-deoxy-N3-methyl-D-streptamine
Trademarks: Destonate 20 (Meiji)
Molecular Formula: C20H37N3O13
Molecular Weight: 527.52
Percent Composition: C 45.54%, H 7.07%, N 7.97%, O 39.43%
Literature References: Aminoglycoside antibiotic, member of the orthosomycin family. Destomycins A, B and C are known; A is the major component. Isoln of A and B from culture broth of Streptomyces rimofaciens: S.-I. Kondo et al., J. Antibiot. 18A, 38 (1965); of C: eidem, ibid. 28, 83 (1975). Prepn: eidem, JP 67 7598 (1967 to Meiji Seika Kaisha). Structure of A: eidem, J. Antibiot. 19A, 139 (1966); of A and B: eidem, ibid. 28, 79 (1975). Stereochemical study: S. Horito et al., Bull. Chem. Soc. Jpn. 54, 2147 (1981). Synthesis of destomycin C: J. Yoshimura et al., Chem. Lett. 1985, 1335; J.-I. Tamura et al., Carbohydr. Res. 174, 181 (1988). Anthelmintic activity in poultry: I. Sawada, Kiseichugaku Zasshi 21, 45 (1972), C.A. 77, 135668j (1972). HPLC determn in pork samples: K. Nakaya et al., Shokuhin Eiseigaku Zasshi 28, 487 (1987), C.A. 109, 5359c (1988).
Properties: White powder, mp 180-190° (dec). [a]D22 +7° (c = 2). Freely sol in water, lower alcohols. Insol or poorly sol in most organic solvents. LD50 in mice (after 2-week observation) (mg/kg): 5-10 i.v.; 50-100 orally (Kondo, 1965).
Melting point: mp 180-190° (dec)
Optical Rotation: [a]D22 +7° (c = 2)
Toxicity data: LD50 in mice (after 2-week observation) (mg/kg): 5-10 i.v.; 50-100 orally (Kondo, 1965)
Therap-Cat-Vet: Broad spectrum antimicrobial; anthelmintic.