Home > Name List By n > N'-[(5-chlorothiophen-2-yl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1, 2-diamine

CAS No 148-65-2 , N'-[(5-chlorothiophen-2-yl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,
2-diamine

  • Name: N'-[(5-chlorothiophen-2-yl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,
    2-diamine
  • Synonyms: Chloropyrilene; Pyrithen; Chlorpyrilenum; Chlorthenylpyramine;N'-[(5-chlorothiophen-2-yl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,
    2-diamine;Histachlorylene; Chlorothenylpyramine; Chloromethapyrilene; CHLOROTHEN;
  • CAS Registry Number:
  • Flash Point: 201°C
  • Boiling Point: 408.8°Cat760mmHg
  • Density: 1.234g/cm3
  • Refractive index: 1.619
  • Safety Statements: Poison by intraperitoneal route. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and SOx.
  • Hazard Symbols: Xi
  • Flash Point: 201°C
  • Molecular Weight: 295.83082
  • InchiKey: XAEXSWVTEJHRMH-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H18ClN3S/c1-17(2)9-10-18(14-5-3-4-8-16-14)11-12-6-7-13(15)
    19-12/h3-8H,9-11H2,1-2H3
  • Molecular Formula: C14H18ClN3S
  • Molecular Structure:CAS No:148-65-2 N'-[(5-chlorothiophen-2-yl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,<br />2-diamine

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References of N'-[(5-chlorothiophen-2-yl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,
2-diamine
Title: Chlorothen
CAS Registry Number: 148-65-2
CAS Name: N-[(5-Chloro-2-thienyl)methyl]-N￠,N￠-dimethyl-N-2-pyridinyl-1,2-ethanediamine
Synonyms: 2-[(5-chloro-2-thenyl)(2-dimethylaminoethyl)amino]pyridine; N,N-dimethyl-N￠-(2-pyridyl)-N￠-(5-chloro-2-thenyl)ethylenediamine; N,N-dimethyl-N￠-(a-pyridyl)-N￠-(2-methyl-5-chlorothienyl)ethylenediamine; N-5-chloro-2-thienylmethyl-N￠,N￠-dimethyl-N-2-pyridylethylenediamine; chloropyrilene; chloromethapyrilene; chlorothenylpyramine
Molecular Formula: C14H18ClN3S
Molecular Weight: 295.83
Percent Composition: C 56.84%, H 6.13%, Cl 11.98%, N 14.20%, S 10.84%
Literature References: Prepd by the condensation of 5-chloro-2-thenyl chloride and N,N-dimethyl-N￠-(2-pyridyl)ethylenediamine in the presence of sodium or potassium amide: R. C. Clapp et al., J. Am. Chem. Soc. 69, 1549 (1947); L. P. Kyrides, US 2581869 (1952 to Monsanto). Toxicity data: J. C. Castillo et al., J. Pharmacol. Exp. Ther. 96, 388 (1949).
Properties: Liquid. bp1.0 155-156°. Strong base.
Boiling point: bp1.0 155-156°
 
Derivative Type: Hydrochloride
Trademarks: Thenclor
Molecular Formula: C14H18ClN3S.HCl
Molecular Weight: 332.29
Percent Composition: C 50.60%, H 5.76%, Cl 21.34%, N 12.65%, S 9.65%
Properties: Crystals, mp 106-108°. Freely sol in water.
Melting point: mp 106-108°
 
Derivative Type: Citrate
CAS Registry Number: 148-64-1
Trademarks: Tagathen (Lederle)
Molecular Formula: C14H18ClN3S.C6H8O7
Molecular Weight: 487.95
Percent Composition: C 49.23%, H 5.37%, Cl 7.27%, N 8.61%, S 6.57%, O 22.95%
Properties: Crystals, mp 112-116°. On further heating gradually solidifies and remelts 125-140° (dec). uv max: 240 nm (E1%1cm 390-410). One gram dissolves in 35 ml water, in about 65 ml alc. Practically insol in ether, chloroform, benzene. pH of 1% aq soln 3.9 to 4.1. LD50 i.p. in mice: 105 mg/kg (Castillo).
Melting point: mp 112-116°
Absorption maximum: uv max: 240 nm (E1%1cm 390-410)
Toxicity data: LD50 i.p. in mice: 105 mg/kg (Castillo)
 
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Ethylenediamine Derivatives.