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CAS No 1477-57-2 , 2,2-dichloro-N-[8-[(2,2-dichloroacetyl)amino]octyl]acetamide

  • Name: 2,2-dichloro-N-[8-[(2,2-dichloroacetyl)amino]octyl]acetamide
  • Synonyms: Bis-Diamine; 1477-57-2; Win 18446; Bisdiamine;2,2-dichloro-N-[8-[(2,2-dichloroacetyl)amino]octyl]acetamide; N,N'-Octamethylenebis(dichloroacetamide); R-010-TK; Fertilysine N; Fertilysine;Fertilysin;
  • CAS Registry Number:
  • Melting Point: 118-120 °C
  • Flash Point: 274.5°C
  • Boiling Point: 530.2°Cat760mmHg
  • Density: 0.726
  • Refractive index: 1.503
  • Safety Statements: Poison by intraperitoneal route. Human systemic effects by ingestion: nausea and vomiting. Human reproductive effects by ingestion: changes in spermatogenesis. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
  • Flash Point: 274.5°C
  • EINECS: 216-033-0
  • Molecular Weight: 366.1114
  • InchiKey: FAOMZVDZARKPFJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H20Cl4N2O2/c13-9(14)11(19)17-7-5-3-1-2-4-6-8-18-12(20)10(15)
    16/h9-10H,1-8H2,(H,17,19)(H,18,20)
  • Risk Statements: S24/25 :Avoid contact with skin and eyes.;
  • Molecular Formula: C12H20Cl4N2O2
  • Molecular Structure:CAS No:1477-57-2 2,2-dichloro-N-[8-[(2,2-dichloroacetyl)amino]octyl]acetamide

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References of 2,2-dichloro-N-[8-[(2,2-dichloroacetyl)amino]octyl]acetamide
Title: Fertilysin
CAS Registry Number: 1477-57-2
CAS Name: N,N￠-1,8-Octanediylbis[2,2-dichloroacetamide]
Synonyms: N,N￠-octamethylenebis(2,2-dichloroacetamide); N,N￠-bis(dichloroacetyl)-1,8-octamethylenediamine
Manufacturers' Codes: Win-18446
Molecular Formula: C12H20Cl4N2O2
Molecular Weight: 366.11
Percent Composition: C 39.37%, H 5.51%, Cl 38.73%, N 7.65%, O 8.74%
Line Formula: Cl2CHCONH(CH2)8NHOCCHCl2
Literature References: Inhibits spermatogenesis without affecting production of gonadotropins in male laboratory animals. Prepn and biological activity: Surrey, Mayer, J. Med. Pharm. Chem. 3, 419 (1961); Surrey, US 3143566 (1964 to Sterling Drug). Assessment of antifertility activity in rats: S. Nag, J. J. Ghosh, J. Steroid Biochem. 11(1B), 681 (1979). Teratological study: P. Taleporos et al., Teratology 18, 5 (1978). Toxicology study: F. Coulston et al., Toxicol. Appl. Pharmacol. 2, 715 (1960).
Properties: Crystals, mp 122.4-123.6°. LD50 orally in mice: >16000 mg/kg (Coulston).
Melting point: mp 122.4-123.6°
Toxicity data: LD50 orally in mice: >16000 mg/kg (Coulston)