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CAS No 14679-73-3 , Hydrazinecarboxylicacid, 2-(1-phthalazinyl)-, ethyl ester

  • Name: Hydrazinecarboxylicacid, 2-(1-phthalazinyl)-, ethyl ester
  • Synonyms: Carbazicacid, 3-(1-phthalazinyl)-, ethyl ester (8CI);N1-Carbethoxy-N2-phthalazinehydrazine;Hydrazinecarboxylicacid, 2-(1-phthalazinyl)-, ethyl ester; Todralazine; Carboethoxyphthalazinohydrazine;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.328g/cm3
  • Safety Statements: Poison by ingestion, intraperitoneal, intravenous, and intramuscular routes. Moderately toxic by ingestion and parenteral routes. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: °C
  • Molecular Weight: 232.27
  • InChI: InChI=1/C11H12N4O2.ClH/c1-2-17-11(16)15-14-10-9-6-4-3-5-8(9)7-12-13-10;/h3-7H,2H2,1H3,(H,13,14)(H,15,16);1H
  • Molecular Formula: C11H12 N4 O2
  • Molecular Structure:CAS No:14679-73-3 Hydrazinecarboxylicacid, 2-(1-phthalazinyl)-, ethyl ester

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References of Hydrazinecarboxylicacid, 2-(1-phthalazinyl)-, ethyl ester
Title: Todralazine
CAS Registry Number: 14679-73-3
CAS Name: 2-(1-Phthalazinyl)hydrazinecarboxylic acid ethyl ester
Synonyms: 3-(1-phthalazinyl)carbazic acid ethyl ester; N1-carbethoxy-N2-phthalazinehydrazine; carboethoxyphthalazinohydrazine; ecarazine
Molecular Formula: C11H12N4O2
Molecular Weight: 232.24
Percent Composition: C 56.89%, H 5.21%, N 24.12%, O 13.78%
Literature References: Prepn: S. Biniecki et al., Bull. Acad. Pol. Sci. Ser. Sci. 6, 227 (1958), C.A. 52, 18424g (1958); eidem, BE 647722; eidem, US 3591588 (1964, 1971 both to Polfa). Spectrofluorometric determn in plasma: A. Ishii, T. Deguchi, Chem. Pharm. Bull. 26, 2241 (1978). Pharmacological study: M. Filczewski, E. Boguka, Pol. J. Pharmacol. Pharm. 31, 127 (1979), C.A. 91, 204508 (1979). Absorption, distribution, excretion in rats and humans: A. Ishii et al., Oyo Yakuri 18, 61 (1979), C.A. 92, 104012 (1980). Clinical study: W. Reiterer, H. Czitober, Arzneim.-Forsch. 27, 2163 (1977). Toxicity study: F. Parravincini et al., Farmaco Ed. Sci. 34, 299 (1979).
 
Derivative Type: Hydrochloride
CAS Registry Number: 3778-76-5
Synonyms: CEPH
Manufacturers' Codes: BT-621
Trademarks: Apiracohl (Kyowa); Aperdor (Tokyo Tanabe); Apride (Kodama); Atapren (Sumitomo); Binazin (Polfa); Illcut (Nippon Zoki); Propat (Hishiyama)
Molecular Formula: C11H12N4O2.HCl
Molecular Weight: 268.70
Percent Composition: C 49.17%, H 4.88%, N 20.85%, O 11.91%, Cl 13.19%
Properties: LD50 i.p. in mice: 500 mg/kg (Parravincini).
Toxicity data: LD50 i.p. in mice: 500 mg/kg (Parravincini)
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Hydrazines/Phthalazines.