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CAS No 146426-40-6 , Flavopiridol Search by region : Germany

  • Name: Flavopiridol
  • Synonyms: Flavopiridol;2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one;
  • CAS Registry Number:
  • Density: 1.448 g/cm3
  • Refractive index: 1.708
  • Water Solubility: Soluble in chloroform; slightly soluble in water.
  • Molecular Weight: 401.84
  • InChI: InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m1/s1
  • Molecular Formula: C21H20ClNO5
  • Molecular Structure:CAS No:146426-40-6 Flavopiridol

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146426-40-6 Flavopiridol Hydrochloride

  • Flavopiridol Hydrochloride
  • Germany SYNCHEM Laborgemeinschaft OHG [Manufacturer]
  • Tel: +49 (0) 5662 40873-0
  • Fax: +49 (0) 5662 40873-20
  • Address: SYNCHEM Laborgemeinschaft OHG
    Dr. Jaeger & Dr. Drinkuth
    Am Kies 2
    D-34587 Felsberg / Altenburg, Germany null,nullGermany
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References of Flavopiridol
Title: Flavopiridol
CAS Registry Number: 146426-40-6
CAS Name: rel-(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one
Synonyms: cis-(-)-2-(2-chlorophenyl)-5,7-dihydroxy-8-[4￠-(3￠-hydroxy-1￠-methyl)-piperidinyl]-4H-1-benzopyran-4-one
Molecular Formula: C21H20ClNO5
Molecular Weight: 401.84
Percent Composition: C 62.77%, H 5.02%, Cl 8.82%, N 3.49%, O 19.91%
Literature References: Flavone inhibitor of cyclin-dependent kinases; the (-)-cis form induces apoptosis in certain tumor cells. Prepn: S. L. Kattige et al., EP 241003; eidem, US 4900727 (1987, 1990 both to Hoechst). Properties and formulation study: R.-M. Dannenfelser et al., PDA J. Pharm. Sci. Technol. 50, 356 (1996). Mode of action study: S. Brüsselbach et al., Int. J. Cancer 77, 146 (1998). Clinical evaluation in refractory cancers: A. M. Senderowicz et al., J. Clin. Oncol. 16, 2986 (1998). Clinical pharmacokinetics: J. P. Thomas et al., Cancer Chemother. Pharmacol. 50, 465 (2002). Review of chemistry, pharmacology, and antitumor spectrum: H. H. Sedlacek et al., Int. J. Oncol. 9, 1143-1168 (1996).
 
Derivative Type: Hydrochloride
CAS Registry Number: 131740-09-5
Manufacturers' Codes: L-86-8275; HMR-1275; NSC-649890
Molecular Formula: C21H20ClNO5.HCl
Molecular Weight: 438.30
Percent Composition: C 57.55%, H 4.83%, Cl 16.18%, N 3.20%, O 18.25%
Properties: mp 169.5± 0.5° (Dannenfelser). Also reported as yellow powder, mp 188° containing 4.73-6.2% water of crystallization (Sedlacek). pKa 5.68 ± 0.06. [a]24D -1.73 to -3.9°. Soly (mg/ml): water, D5W, and normal saline all <5 at pH 4. Soly (mg/ml): ethanol 10.1; PEG 400 >73.8; propylene glycol >88.1; M-pyrol very much greater than 103.0; t-butyrolactone very much greater than 105.5.
Melting point: mp 169.5± 0.5° (Dannenfelser); mp 188°
pKa: pKa 5.68 ± 0.06
Optical Rotation: [a]24D -1.73 to -3.9°
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic.