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CAS No 145808-47-5 , Margatoxin (9CI)

  • Name: Margatoxin (9CI)
  • Synonyms: Margatoxin (9CI);29),(13®27: PN:WO2008088422 FIGURE: 7A claimed protein;34),(17®36)-tris(disulfide); L-Histidine,L-threonyl-L-isoleucyl-L-isoleucyl-L-asparaginyl-L-valyl-L-lysyl-L-cysteinyl-L-threonyl-L-seryl-L-prolyl-L-lysyl-L-glutaminyl-L-cysteinyl-L-leucyl-L-prolyl-L-prolyl-L-cysteinyl-L-lysyl-L-alanyl-L-glutaminyl-L-phenylalanylglycyl-L-glutaminyl-L-seryl-L-alanylglycyl-L-alanyl-L-lysyl-L-cysteinyl-L-methionyl-L-asparaginylglycyl-L-lysyl-L-cysteinyl-L-lysyl-L-cysteinyl-L-tyrosyl-L-prolyl-,cyclic (7®
  • CAS Registry Number:
  • Safety Statements: 22
  • Molecular Weight: 4178.95
  • Molecular Formula: C178H286N52O50S7

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145808-47-5 H-2192.0100 H-THR-ILE-ILE-ASN-VAL-LYS-CYS-THR-SER-PRO-LYS-GLN-CYS-LEU-PRO-PRO-CYS-LYS-ALA-GLN-PHE-GLY-GLN-SER-ALA-GLY-ALA-LYS-CYS-MET-ASN-GLY-LYS-CYS-LYS-CYS-TYR-PRO-HIS-OH, (DISULFIDE BONDS BETWEEN CYS7 AND CYS29/CYS13 AND CYS34/ CYS17 AND CYS36)

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145808-47-5 MARGATOXIN (MGTX)

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References of Margatoxin (9CI)
Title: Margatoxin
CAS Registry Number: 145808-47-5
Synonyms: MgTX
Molecular Formula: C178H286N52O50S7
Molecular Weight: 4178.95
Percent Composition: C 51.16%, H 6.90%, N 17.43%, O 19.14%, S 5.37%
Literature References: Peptide toxin isolated from the new world scorpion, Centruroides margaritatus, consists of 39 amino acids with 3 disulfide bridges. Selectively inhibits voltage-gated potassium channels. Isoln and characterization: M. Garcia-Calvo et al., J. Biol. Chem. 268, 18866 (1993). Synthesis: M. A. Bednarek et al., Biochem. Biophys. Res. Commun. 198, 619 (1994). NMR determn of three dimensional structure: B. A. Johnson et al., Biochemistry 33, 15061 (1994). Use as an affinity label for potassium channels: H.-G. Knaus et al., ibid. 34, 13627 (1995); H. S. Fischer, A. Saria, Neurosci. Lett. 263, 208 (1999).
Use: Biochemical probe.