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CAS No 144875-48-9 , R 848

  • Name: R 848
  • Synonyms: Chebi:36706;R 848;1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-C]quinolin-1-yl]-2-methylpropan-2-ol;RESIQUIMOD;
  • CAS Registry Number:
  • Flash Point: 288.6°C
  • Boiling Point: 553.6°Cat760mmHg
  • Density: 1.28g/cm3
  • Refractive index: 1.634
  • Flash Point: 288.6°C
  • Molecular Weight: 0
  • InChI: InChI=1/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)
  • Molecular Formula: C17H22N4O2
  • Molecular Structure:CAS No:144875-48-9 R 848

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References of R 848
Title: Resiquimod
CAS Registry Number: 144875-48-9
CAS Name: 4-Amino-2-(ethoxymethyl)-a,a-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol
Manufacturers' Codes: R-848; S-28463
Molecular Formula: C17H22N4O2
Molecular Weight: 314.38
Percent Composition: C 64.95%, H 7.05%, N 17.82%, O 10.18%
Literature References: Immune response modulator structurally similar to imiquimod, q.v. Induces cytokine secretion by monocytes and activates antibody secretion by B cells. Prepn: J. F. Gerster et al., WO 9215582; eidem, US 5389640 (1992, 1995 both to 3M). Immunomodulating and antiviral activities: M. A. Tomai et al., Antiviral Res. 28, 253 (1995). Mechanism of action study: G. A. Bishop et al., Cell. Immunol. 208, 9 (2001). Clinical evaluation in genital herpes: S. L. Spruance et al., J. Infect. Dis. 184, 196 (2001). Review of development: J. J. Wu et al., Antiviral Res. 64, 79-83 (2004).
Properties: Colorless, crystalline solid, mp 190-193°.
Melting point: mp 190-193°
Therap-Cat: Antiviral.
Keywords: Antiviral; Imidazoquinolines; Immunomodulator.