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CAS No 144060-53-7 , 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic
acid

  • Name: 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic
    acid
  • Synonyms: Tei-6720;2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic
    acid; Adenuric;144060-53-7; 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid; TMX 67; Tei 6720; TMX-67; Uloric;
  • CAS Registry Number:
  • Density: 1.31 g/cm3
  • Refractive index: 1.605
  • Molecular Weight: 316.37484
  • InchiKey: BQSJTQLCZDPROO-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14
    (22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20)
  • Molecular Formula: C16H16N2O3S
  • Molecular Structure:CAS No:144060-53-7 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic<br />acid

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References of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic
acid
Title: Febuxostat
CAS Registry Number: 144060-53-7
CAS Name: 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
Synonyms: 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid
Manufacturers' Codes: TEI-6720; TMX-67
Molecular Formula: C16H16N2O3S
Molecular Weight: 316.37
Percent Composition: C 60.74%, H 5.10%, N 8.85%, O 15.17%, S 10.14%
Literature References: Xanthine oxidase/xanthine dehydrogenase inhibitor. Prepn: S. Kondo et al., EP 513379; eidem, US 5614520 (1992, 1997 both to Teijin). Synthesis: M. Hasegawa, Heterocycles 47, 857 (1998). Mechanism of action and crystal structure study: K. Okamoto et al., J. Biol. Chem. 278, 1848 (2003). Pharmacology: Y. Osada et al., Eur. J. Pharmacol. 241, 183 (1993). Clinical pharmacokinetics: M. D. Mayer et al., Am. J. Therap. 12, 22 (2005). Clinical evaluation in hyperuricemia and gout: M. A. Becker et al., N. Engl. J. Med. 353, 2450 (2005). Review of clinical development: B. Tomlinson, Curr. Opin. Invest. Drugs 6, 1168-1178 (2005).
Properties: Crystals from ethanol, mp 238-239° (dec). Also reported as crystals from acetone, mp 201-202° (Hasegawa).
Melting point: mp 238-239° (dec); mp 201-202° (Hasegawa)
Therap-Cat: Treatment of hyperuricemia and chronic gout.
Keywords: Antigout; Xanthine Oxidase Inhibitor.