Home > Name List By n > N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine

CAS No 144034-80-0 , N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine

  • Name: N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
  • Synonyms: Rizatriptan benzoat;Risatriptan;N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine; Rizatriptan (INN); Rizatriptan [INN:BAN]; rizatriptanum; MK 462 free base; 144034-80-0; CHEBI:48273;
  • CAS Registry Number:
  • Melting Point: 178-180 ºC
  • Flash Point: 259.1°C
  • Boiling Point: 504.8°Cat760mmHg
  • Density: 1.21g/cm3
  • Water Solubility: 42 MG/ML
  • Flash Point: 259.1°C
  • Molecular Weight: 269.34486
  • InchiKey: ULFRLSNUDGIQQP-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H19N5/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-
    10-18-20/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3
  • Molecular Formula: C15H19N5
  • Molecular Structure:CAS No:144034-80-0 N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine

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References of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
Title: Rizatriptan
CAS Registry Number: 144034-80-0
CAS Name: N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine
Synonyms: 3-[2-(dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)indole; N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3yl]ethylamine
Molecular Formula: C15H19N5
Molecular Weight: 269.34
Percent Composition: C 66.89%, H 7.11%, N 26.00%
Literature References: Selective serotonin 5-HT1D receptor agonist; structurally derived from tryptamine. Prepn: R. Baker et al., EP 497512; eidem, US 5298520 (1992, 1994 both to Merck Sharp & Dohme); and binding characteristics: L. J. Street et al., J. Med. Chem. 38, 1799 (1995). Synthesis: C. Chen et al., Tetrahedron Lett. 35, 6981 (1994). Clinical pharmacokinetics: H. Cheng et al., Biopharm. Drug Dispos. 17, 17 (1996). LC-MS determn in plasma: D. A. McLoughlin et al., J. Chromatogr. A 726, 115 (1996). Comparative clinical trial in treatment of migraine: J. U. Adelman et al., Neurology 57, 1377 (2001). Review of pharmacology and therapeutic efficacy: K. Wellington, G. L. Plosker, Drugs 62, 1539-1574 (2002).
Properties: mp 120-121°.
Melting point: mp 120-121°
 
Derivative Type: Benzoate
CAS Registry Number: 145202-66-0
Manufacturers' Codes: MK-0462; MK-462
Trademarks: Maxalt (Merck & Co.)
Molecular Formula: C15H19N5.C6H5COOH
Molecular Weight: 391.47
Percent Composition: C 67.50%, H 6.44%, N 17.89%, O 8.17%
Properties: mp 178-180°.
Melting point: mp 178-180°
 
Therap-Cat: Antimigraine.
Keywords: Antimigraine; Serotonin Receptor Agonist.