Title: Protionamide
CAS Registry Number: 14222-60-7
CAS Name: 2-Propyl-4-pyridinecarbothioamide
Synonyms: 2-propylthioisonicotinamide; prothionamide; 2-propyl-4-thiocarbamoylpyridine
Trademarks: Ektebin (Hefa); Peteha (Fatol); Trevintix (Th?aplix)
Molecular Formula: C9H12N2S
Molecular Weight: 180.27
Percent Composition: C 59.96%, H 6.71%, N 15.54%, S 17.79%
Literature References: Prepn: D. Liberman
et al., Compt. Rend. 242, 2409 (1956);
GB 800250, D. Liberman,
US 2901488 (1958, 1959 both to Chimie et Atomistique); L. N. Yakhontov
et al., Khim. Farm. Zh. 10, 96 (1976),
C.A. 85, 32787h (1976). Pharmacology: A. M. Il'in,
Farmakol. Toksikol. 38, 471 (1975).
Properties: Crystals, mp 142°. Sol in ethanol, methanol; slightly sol in ether, chloroform. Practically insol in water. LD50 in mice, rats (g/kg): 1.0, 1.32 orally (Il'in).
Melting point: mp 142°
Toxicity data: LD50 in mice, rats (g/kg): 1.0, 1.32 orally (Il'in)
Therap-Cat: Antibacterial (tuberculostatic).
Keywords: Antibacterial (Tuberculostatic).