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CAS No 1403-71-0 , Hamycin

  • Name: Hamycin
  • Synonyms: Hamycin;Primamycin;
  • CAS Registry Number:
  • Safety Statements: Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion.
  • Molecular Weight: 0
1/1
References of Hamycin
Title: Hamycin
CAS Registry Number: 1403-71-0
Synonyms: Primamycin
Literature References: Polyene antibiotic complex produced by Streptomyces pimprina: M. J. Thirumalachar et al., Hind. Antibiot. Bull. 3, 136 (1961), C.A. 55, 27515i (1961); M. J. Thirumalachar, US 3261751 (1966 to Hindustan Antibiot.). Formerly believed to be identical to trichomycin and candicidin, q.q.v.: H. Burrows, D. Calam, J. Chromatogr. 53, 566 (1970). Subsequent HPLC studies have shown the three polyene antibiotics to be different entities: P. Helboe et al., ibid. 189, 249 (1980). Structural study showing hamycin to be a mixture of components A, B, C, D: R. C. Pandey, K. L. Rinehart, 16th Interscience Conference on Antimicrob. Ag. Chemother., Chicago, 1976, Abstracts of Papers, no. 41. Absorption, excretion, tissue concentration: M. G. Phatak et al., Indian J. Exp. Biol. 12, 284 (1974), C.A. 82, 118703j (1975). Toxicity studies: Williams et al., Antimicrob. Agents Chemother. 1964, 737; antifungal activity: A. C. Parekh, C. V. Dave, Life Sci. 19, 1737 (1976). HPLC study: W. Mechlinski, C. P. Schaffner, J. Antibiot. 33, 591 (1980). Review of clinical use in mycoses: M. J. Thirumalachar, J. Sci. Ind. Res. 31, 542-544 (1972), C.A. 79, 13308 (1973).
Properties: Yellow amorphous powder, no definite mp, decomp 160°. [a]D25+216°. uv max (80% methanol): 383 nm (E1%1cm 916). An amphoteric compd. Almost insol in water, benzene, chloroform, dry lower aliphatic alcohols, ether. Sol in basic solvents such as pyridine, collidine, and in aq lower alcohols. In concd H2SO4 gives stable blue color; no coloration with ferric chloride or with HCl. LD50 i.v. in mice (using sodium carboxymethyl cellulose as a vehicle): 6.16 mg/kg (Williams). Also reported as LD50 i.v. in Swiss mice (using a colloidal suspension): 1.20 mg/kg (Parekh, Dave).
Optical Rotation: [a]D25+216°
Absorption maximum: uv max (80% methanol): 383 nm (E1%1cm 916)
Toxicity data: LD50 i.v. in mice (using sodium carboxymethyl cellulose as a vehicle): 6.16 mg/kg (Williams); LD50 i.v. in Swiss mice (using a colloidal suspension): 1.20 mg/kg (Parekh, Dave)
 
Derivative Type: Hamycin A
Properties: mp >300° (dec), [a]D24 +181.1° (c = 0.6 in DMF). uv max: 380 nm (E1%1cm 989).
Melting point: mp >300° (dec)
Optical Rotation: [a]D24 +181.1° (c = 0.6 in DMF)
Absorption maximum: uv max: 380 nm (E1%1cm 989)
 
Therap-Cat: Antifungal.
Keywords: Antifungal (Antibiotics); Polyenes.