Title: Cyacetacide
CAS Registry Number: 140-87-4
CAS Name: Cyanoacetic acid hydrazide
Synonyms: malononitrile hydrazide; cyanoacetohydrazide; cyanazide; cyanizide; cyanacethydrazine; cyanacethydrazide; cyanoethydrazide; cyanacetylhydrazide
Trademarks: Dictyzide; Mackreazid; Armazal; Reacid; Reazide; Hidacian; Leandin; Neohydrazid; Dictycide (Fort Dodge)
Molecular Formula: C3H5N3O
Molecular Weight: 99.09
Percent Composition: C 36.36%, H 5.09%, N 42.41%, O 16.15%
Line Formula: NCCH2CONHNH2
Literature References: Prepd by boiling ethyl or methyl cyanoacetate with hydrazine hydrate in alc: Rothenburg,
Ber. 27, 687 (1894); Darapsky, Hillers,
J. Prakt. Chem. 92[2], 313 (1915); Klosa,
Arch. Pharm. 288, 453 (1955). Prepn of dosage forms: Muset,
US 2849369 (1958 to Labs OM).
Properties: Stout prisms from alc, mp 114.5-115° (evac tube). Rapidly dec by heat. Very slightly acid to litmus. Very sol in water. Sol in alcohol. Practically insol in ether. Aq solns become discolored after a few days and the pH becomes alkaline.
Melting point: mp 114.5-115° (evac tube)
Derivative Type: Hydrochloride
Molecular Formula: C3H5N3O.HCl
Molecular Weight: 135.55
Percent Composition: C 26.58%, H 4.46%, N 31.00%, O 11.80%, Cl 26.15%
Properties: Crystals, mp 145°. Freely sol in water. Acid reaction. Aq solns are more stable than those of the free hydrazide.
Melting point: mp 145°
Therap-Cat: Antibacterial (tuberculostatic).
Therap-Cat-Vet: Anthelmintic (lungworms).
Keywords: Antibacterial (Tuberculostatic).
