Title: Hachimycin
CAS Registry Number: 1394-02-1
CAS Name: Trichomycin
Trademarks: Trichonat (Grñenthal)
Literature References: Heptaene macrolide antibiotic substance produced by
Streptomyces hachijoensis from soil of the Pacific Island Hachijo Jima: S. Hosoya
et al., J. Antibiot. 5, 564 (1952); T. Yamaguchi,
ibid. 7A, 10 (1954). Purification and prepn of insol derivs: S. Hosoya
et al., ibid. 8A, 5 (1955). At one time, trichomycin was believed to be identical to candicidin and hamycin,
q.q.v.: H. Burrows, D. Calam,
J. Chromatogr. 53, 566 (1970). Subsequent HPLC studies have shown the three polyene antibiotics to be different entities: P. Helboe
et al., ibid. 189, 249 (1980). Active against
Trichomonas vaginalis, Treponema pallidum, Trichophyton, Candida, and yeast, weak activity against
Aspergillus and
Penicillium: T. Yamaguchi,
J. Antibiot. 7A, 10 (1954). Toxicity: S. Hosoya
et al., J. Antibiot. 6A, 98 (1953).
Review: S. A. Waksman, H. A. Lechevalier,
The Actinomycetes vol. III (Williams & Wilkins, Baltimore, 1962) pp 397-399.
Properties: Yellow crystals. Acid reaction. Forms a water-sol sodium salt. Can be pptd as a water-insol salt by acridine derivs such as acriflavine, by sulfa drugs such as homosulfanilamide, by basic antibiotics such as streptomycin base, by enzymes such as papain and lysozyme, by dyes such as methylene blue, and by metallic salts such as CaCl2. LD50 i.p. in mice: 0.05 mg/10-12 g mouse (Hosoya).
Toxicity data: LD50 i.p. in mice: 0.05 mg/10-12 g mouse (Hosoya)
Therap-Cat: Antifungal. Antiprotozoal (Trichomonas).
Keywords: Antifungal (Antibiotics); Polyenes; Antiprotozoal (Trichomonas).
