CAS No 138112-76-2 , N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide Search by region : India

Name: N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
Synonyms: Agomelatine; S20098;N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide; S1243_Selleck; Agomelatine (INN); Valdoxan (TN); Melitor; Valdoxan; Agomelatine [INN]; Thymanax; 138112-76-2;
CAS Registry Number:138112-76-2
Density: 1.109g/cm³
Molecular Weight: 243.30098
InchiKey: YJYPHIXNFHFHND-UHFFFAOYSA-N
InChI: InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/
h3-7,10H,8-9H2,1-2H3,(H,16,17)
Molecular Formula: C₁₅H₁₇NO₂
Molecular Structure:

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           138112-76-2 AGOMELATINE 
           
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           138112-76-2 Agomelatine
           
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References of N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide

Title: Agomelatine
CAS Registry Number: 138112-76-2
CAS Name: N-[2-(7-Methoxy-1-naphthalenyl)ethyl]acetamide
Manufacturers' Codes: S-20098
Trademarks: Valdoxan (Biopharma)
Molecular Formula: C15H17NO2
Molecular Weight: 243.30
Percent Composition: C 74.05%, H 7.04%, N 5.76%, O 13.15%
Literature References: Melatoninergic agonist and selective serotonin 5-HT2B and 5-HT2C receptor antagonist; metabolically stable analogue of melatonin, q.v. Prepn: J. Andrieux et al., EP 447285; eidem, US 5225442 (1991, 1993 both to Adir); and structure-activity studies: S. Yous et al., J. Med. Chem. 35, 1484 (1992); P. Depreux et al., ibid. 37, 3231 (1994). Mechanism of action: M. J. Millan et al., J. Pharmacol. Exp. Ther. 306, 954 (2003). Clinical evaluation in major depressive disorder: H. L?o et al., Int. Clin. Psychopharmacol. 17, 239 (2002); S. H. Kennedy, R. Emsley, Eur. Neuropsychopharmacol. 16, 93 (2006).
Properties: Crystals from toluene + hexane, 2:1, mp 109-110°.
Melting point: mp 109-110°
Therap-Cat: Antidepressant.
Keywords: Serotonin Receptor Antagonist; Antidepressant.