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CAS No 137071-32-0 , Pimecrolimus

  • Name: Pimecrolimus
  • Synonyms: Elidel;Picrolimus; ASM 981; SDZ-ASM 981;Pimecrolimus;
  • CAS Registry Number:
  • Density: 1.19
  • Refractive index: 1.543
  • Water Solubility: Soluble in DMSO and ethanol, up to about 25 mg/mL
  • Molecular Weight: 810.45
  • InChI: InChI=1S/C43H68ClNO11/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-31(44)35(22-29)52-7/h18,20,25,27-33,35-39,46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32-,33-,35+,36-,37-,38+,39+,43+/m0/s1
  • Molecular Formula: C43H68ClNO11
  • Molecular Structure:CAS No:137071-32-0 Pimecrolimus

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137071-32-0 PIMECROLIMUS

  • Canada Molcan Corporation [Manufacturer]
  • Tel: 905-731-5537/ 888-237-7579
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  • Address: 70 East Beaver Creek Road 39,
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  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
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  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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  • China Hangzhou Yanshan Chemical Co.,Ltd [Manufacturer]
  • Tel: 86-571-86696867/ 86-571-86897279
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  • Address: Hangzhou Yanshan Chemical Co.,Ltd
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  • China Nanjing Samwon International Limited [Importer/Exporter]
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  • Address: 1108, BLDG B, New Century Plaza, No 1, South Taiping Rd., Nanjing, Jiangsu 210002, Nanjing,JiangsuChina
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137071-32-0 PIMECROLIMUS ELIDEL; SDZ-ASM-981; D05480

  • United States LC Laboratories [Manufacturer]
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References of Pimecrolimus
Title: Pimecrolimus
CAS Registry Number: 137071-32-0
CAS Name: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
Synonyms: 33-epi-chloro-33-desoxyascomycin
Manufacturers' Codes: SDZ-ASM-981
Trademarks: Elidel (Novartis)
Molecular Formula: C43H68ClNO11
Molecular Weight: 810.45
Percent Composition: C 63.73%, H 8.46%, Cl 4.37%, N 1.73%, O 21.72%
Literature References: Macrolactam ascomycin derivative; inhibits production of pro-inflammatory cytokines by T cells and mast cells. Prepn: K. Baumann, G. Emmer, EP 427680 (1991 to Sandoz); eidem, US 5912238 (1999 to Novartis). In vitro pharmacology: M. Gassberger et al., Br. J. Dermatol. 141, 264 (1999). Clinical evaluation in psoriasis: U. Mrowietz et al., ibid. 139, 992 (1998); in contact dermatitis: C. Queille-Roussel et al., Contact Dermatitis 42, 349 (2000).
Therap-Cat: Immunosuppresant.
Keywords: Immunosuppressant.