Home > Name List By 2 > 2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2- oxoethyl]benzoic acid China

CAS No 135062-02-1 , 2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-
oxoethyl]benzoic acid Search by region : China

  • Name: 2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-
    oxoethyl]benzoic acid
  • Synonyms: NovoNorm; 135062-02-1; AG-EE 388 ZW;Prandin; Repaglinida [INN-Spanish]; Repaglinidum [INN-Latin]; AG-EE 623 ZW;2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-
    oxoethyl]benzoic acid; GlucoNorm;
  • CAS Registry Number:
  • Melting Point: 129-130 ºC
  • Density: 1.137 g/cm3
  • Water Solubility: DMSO: 34 mg/mL
  • Molecular Weight: 452.58574
  • InchiKey: FAEKWTJYAYMJKF-QHCPKHFHSA-N
  • InChI: InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23
    (16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,
    4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1
  • Molecular Formula: C27H36N2O4
  • Molecular Structure:CAS No:135062-02-1 2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-<br />oxoethyl]benzoic acid

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References of 2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-
oxoethyl]benzoic acid
Title: Repaglinide
CAS Registry Number: 135062-02-1
CAS Name: 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid
Synonyms: (+)-2-ethoxy-a-[[(S)-a-isobutyl-o-piperidinobenzyl]carbamoyl]-p-toluic acid; (S)-(+)-2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid
Manufacturers' Codes: AG-EE-623 ZW
Trademarks: Novonorm (Novo Nordisk); Prandin (Novo Nordisk)
Molecular Formula: C27H36N2O4
Molecular Weight: 452.59
Percent Composition: C 71.65%, H 8.02%, N 6.19%, O 14.14%
Literature References: Non-sulfonylurea oral hypoglycemic agent. Prepn: W. Grell et al., WO 9300337 (1993 to Thomae). HPLC determn of racemate in human plasma: A. Greischel et al., J. Chromatogr. 568, 246 (1991). Clinical pharmacokinetics: F. J. Ampudia-Blasco et al., Diabetologia 37, 703 (1994). Comparative clinical evaluation in NIDDM: B. H. R. Wolffenbuttel et al., Eur. J. Clin. Pharmacol. 45, 113 (1993).
Properties: White, odorless, crystalline powder. Crystals from ethanol/water (2:1), mp 126-128°. Crystals from neutralized water, mp 130-131°. [a]D20 +6.97° (c = 0.975 in methanol); [a]D20 +7.45° (c = 1.06 in methanol). LD50 orally in rats: >1 g/kg (Grell).
Melting point: mp 126-128°; mp 130-131°
Optical Rotation: [a]D20 +6.97° (c = 0.975 in methanol); [a]D20 +7.45° (c = 1.06 in methanol)
Toxicity data: LD50 orally in rats: >1 g/kg (Grell)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic.