Home > Name List By b > benzyl (2S)-2-[[(2S)-2-acetylsulfanyl-3-(1, 3-benzodioxol-5-yl)-2-methylpropanoyl]amino]propanoate

CAS No 135038-57-2 , benzyl
(2S)-2-[[(2S)-2-acetylsulfanyl-3-(1,
3-benzodioxol-5-yl)-2-methylpropanoyl]amino]propanoate

  • Name: benzyl
    (2S)-2-[[(2S)-2-acetylsulfanyl-3-(1,
    3-benzodioxol-5-yl)-2-methylpropanoyl]amino]propanoate
  • Synonyms: 99544-EP2301923A1;benzyl
    (2S)-2-[[(2S)-2-acetylsulfanyl-3-(1,
    3-benzodioxol-5-yl)-2-methylpropanoyl]amino]propanoate;Fasidotril; 99544-EP2298779A1; 99544-EP2301931A1; UNII-BIB7HG2V9E; AC1L2ZWT; 99544-EP2270011A1; DNC000639;
  • CAS Registry Number:
  • Flash Point: 332°C
  • Boiling Point: 625.3°Cat760mmHg
  • Density: 1.276g/cm3
  • Refractive index: 1.587
  • Flash Point: 332°C
  • Molecular Weight: 443.5127
  • InchiKey: HJUXZNGHXWIRNF-WNSKOXEYSA-N
  • InChI: InChI=1S/C23H25NO6S/c1-15(21(26)28-13-17-7-5-4-6-8-17)24-22(27)23(3,
    31-16(2)25)12-18-9-10-19-20(11-18)30-14-29-19/h4-11,15H,12-14H2,1-3H3,
    (H,24,27)/t15-,23-/m0/s1
  • Molecular Formula: C23H25NO6S
  • Molecular Structure:CAS No:135038-57-2 benzyl<br />(2S)-2-[[(2S)-2-acetylsulfanyl-3-(1,<br />3-benzodioxol-5-yl)-2-methylpropanoyl]amino]propanoate

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135038-57-2 Fasidotril

  • Fasidotril, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
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  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
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135038-57-2 Fasidotril

  • China Zibo Boke T&I Co., Ltd. null
  • Tel: +86-533-2362137
  • Fax: 86-533-2362170
  • Address: Zibo City ,Shandong,China null,ShandongChina
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135038-57-2 FASIDOTRIL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of benzyl
(2S)-2-[[(2S)-2-acetylsulfanyl-3-(1,
3-benzodioxol-5-yl)-2-methylpropanoyl]amino]propanoate
Title: Fasidotril
CAS Registry Number: 135038-57-2
CAS Name: N-[(2S)-3-(Acetylthio)-2-(1,3-benzodioxol-5-ylmethyl)-1-oxopropyl]-L-alanine phenylmethyl ester
Synonyms: N-[(S)-a-(mercaptomethyl)-3,4-(methylenedioxy)-hydrocinnamoyl]-L-alanine, benzyl ester acetate (ester); aladotril; alatriopril
Manufacturers' Codes: BP-1137
Molecular Formula: C23H25NO6S
Molecular Weight: 443.51
Percent Composition: C 62.29%, H 5.68%, N 3.16%, O 21.64%, S 7.23%
Literature References: Vasopeptidase inhibitor (VPI) exhibiting characteristic dual metalloprotease inhibition of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE). Prepn: J.-C. Plaquevent et al., EP 419327; eidem, US 5670531 (1991, 1997 both to Soc. Civile Bioprojet). Absolute configuration: V. Grosset et al., Tetrahedron: Asymmetry 14, 2335 (2003). Enzyme inhibition activity: C. Gros et al., Proc. Natl. Acad. Sci. USA 88, 4210 (1991). Preclinical and clinical pharmacology: S. Laurent et al., Hypertension 35, 1148 (2000). Review of design and pharmacology: J. Bralet et al., Cardiovasc. Drug Rev. 18, 1-24 (2000); of therapeutic potential: F. Ozdener, V. Ozdemir, Curr. Opin. Invest. Drugs 4, 1113-1119 (2003).
Properties: mp 104°. [a]D25 -50.6° (c = 1.35 in methanol). Also reported as white to yellowish microcrystalline powder, mp 108° (Bralet). Sol in acetone, chloroform, dimethylformamide. Nearly insol in water.
Melting point: mp 104°; mp 108° (Bralet)
Optical Rotation: [a]D25 -50.6° (c = 1.35 in methanol)
 
Derivative Type: Diacid
CAS Registry Number: 135038-59-4
Synonyms: Alatrioprilat; fasidotrilat
Molecular Formula: C14H17NO5S
Molecular Weight: 311.35
Percent Composition: C 54.01%, H 5.50%, N 4.50%, O 25.69%, S 10.30%
Properties: Biologically active metabolite. [a]D25 +12.9° (c = 1.3 in methanol).
Optical Rotation: [a]D25 +12.9° (c = 1.3 in methanol)
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Vasopeptidase Inhibitor.