Title: Rasburicase
CAS Registry Number: 134774-45-1
CAS Name: Urate oxidase (
Aspergillus flavus clone 9C/9A reduced)
Manufacturers' Codes: SR-29142
Trademarks: Elitek (Sanofi-Aventis); Fasturtec (Sanofi-Aventis)
Literature References: Recombinant form of fungal urate oxidase expressed in
Saccharomycese cerevisiae; converts uric acid into the more soluble compound, allantoin, which is readily excreted by the kidneys. The natural enzyme is endogenous in most mammals but is absent in higher primates where uric acid is the end-product of purine metabolism. Prepn: D. Caput
et al., EP 408461;
eidem,
US 5382518 (1991, 1995 both to Sanofi); P. Leplatois
et al., Gene 122, 139 (1992). Comparison with natural enzyme: A. Bayol
et al., Biotechnol. Appl. Biochem. 36, 21 (2002). Radioimmunoassay in plasma: D. Dussossoy
et al., J. Pharm. Sci. 85, 955 (1996). Clinical pharmacokinetics in cancer patients: C.-H. Pui
et al., J. Clin. Oncol. 19, 697 (2001). Clinical comparison with allopurinol in pediatric hyperuricemia: S. C. Goldman
et al., Blood 97, 2998 (2001).
Review: C.-H. Pui,
Expert Opin. Pharmacother. 3, 433-452 (2002); V. Oldfield, C. M. Perry,
Drugs 66, 529-545 (2006).
Therap-Cat: In treatment of malignancy associated hyperuricemia.
