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CAS No 13311-84-7 , 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide Search by region : China

  • Name: 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
  • Synonyms: Eulexin;2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; 13311-84-7; niftolid; Cebatrol; Niftholide; veterinary; Flutamin; NFBA; Drogenil; Niftolide;
  • CAS Registry Number:
  • Melting Point: 112 °C
  • Density: 1.372 g/cm3
  • Refractive index: 1.477
  • Water Solubility: Insoluble
  • Safety Statements: R20/21/22;R63
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 236-341-9
  • Molecular Weight: 276.21185
  • InchiKey: MKXKFYHWDHIYRV-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,
    13)14/h3-6H,1-2H3,(H,15,17)
  • Risk Statements: S22;S36
  • Molecular Formula: C11H11F3N2O3
  • Molecular Structure:CAS No:13311-84-7 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

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References of 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Title: Flutamide
CAS Registry Number: 13311-84-7
CAS Name: 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Synonyms: a,a,a-trifluoro-2-methyl-4￠-nitro-m-propionotoluidide; 4￠-nitro-3￠-trifluoromethylisobutyranilide; niftolid
Manufacturers' Codes: Sch-13521
Trademarks: Drogenil (Schering); Eulexin (Schering); Euflex (Schering); Flucinom (Schering); Flutamin (Merck KGaA); Fugerel (Schering)
Molecular Formula: C11H11F3N2O3
Molecular Weight: 276.21
Percent Composition: C 47.83%, H 4.01%, F 20.63%, N 10.14%, O 17.38%
Literature References: Prepn: Baker et al., J. Med. Chem. 10, 93 (1967); Neri, Topliss, DE 2130450 (1972 to Sherico), C.A. 78, 58091g (1973); Gold, DE 2261293; idem, US 3847988 (1973, 1974 both to Schering). Activity studies: Neri et al., Endocrinology 91, 427 (1972); Peets et al., ibid. 94, 532 (1974); B. A. Gladue, L. G. Clemens, Endocrinology 106, 1917 (1980). Effect in prostatic cancer: P. C. Sogani, W. F. Whitmore, J. Urol. 122, 640 (1979). Clinical evaluation in pancreatic cancer: B. A. Greenway, Br. Med. J. 316, 1935 (1998).
Properties: Crystals from benzene, mp 111.5-112.5°.
Melting point: mp 111.5-112.5°
Therap-Cat: Antiandrogen; antineoplastic (hormonal).
Therap-Cat-Vet: Antiandrogen.
Keywords: Antiandrogen; Antineoplastic (Hormonal); Antiandrogens.