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CAS No 133107-64-9 , Insulin (human),28B-L-lysine-29B-L-proline-

  • Name: Insulin (human),28B-L-lysine-29B-L-proline-
  • Synonyms: LY 275585;Insulin (human),28B-L-lysine-29B-L-proline-; 3: PN:WO2004005342 PAGE: 46 claimed protein; Humalog; [Lys(B28), Pro(B29)]-Human insulin;3,4,44,45,90,91-Hexathia-8,11,14,17,20,23,26,29,32,35,38,41,48,51,54,57,60,63,66,69,72,75,78,81,84,86-hexacosaazabicyclo[72.11.7]dononacontane,cyclic peptide deriv.; Humalog Lispro; 28B-L-Lysine-29B-L-prolineinsulin (human); Humalog R;Insulin(ox),8A-L-threonine-10A-L-isoleucine-28B-L-lysine-29B-L-proline-30B-L-threonine-; Lispro;Insulin lispro;
  • CAS Registry Number:
  • Molecular Weight: 0
  • InChI: InChI=1S/C158H234N40O42S2.C99H155N25O35S4/c1-79(2)57-104(181-131(213)86(15)173-136(218)102(50-53-125(211)212)179-152(234)127(84(11)12)194-148(230)107(60-82(7)8)184-145(227)113(67-95-70-166-78-172-95)189-150(232)115(74-199)176-123(208)73-170-134(216)116(75-241)191-140(222)105(58-80(3)4)182-144(226)112(66-94-69-165-77-171-94)188-138(220)101(48-51-119(161)204)178-146(228)114(68-120(162)205)190-153(235)126(83(9)10)193-132(214)98(160)61-89-31-21-18-22-32-89)139(221)185-110(64-92-40-44-96(202)45-41-92)142(224)183-106(59-81(5)6)147(229)195-128(85(13)14)154(236)192-117(76-242)135(217)169-71-121(206)174-100(49-52-124(209)210)137(219)177-99(38-29-55-167-158(163)164)133(215)168-72-122(207)175-108(62-90-33-23-19-24-34-90)141(223)186-109(63-91-35-25-20-26-36-91)143(225)187-111(65-93-42-46-97(203)47-43-93)149(231)196-129(87(16)200)155(237)180-103(37-27-28-54-159)156(238)198-56-30-39-118(198)151(233)197-130(88(17)201)157(239)240;1-12-46(9)77(121-73(134)36-100)97(156)122-76(45(7)8)95(154)108-56(25-29-75(137)138)80(139)105-54(23-27-70(102)131)83(142)117-66(40-161)93(152)119-68(42-163)94(153)124-79(48(11)127)98(157)116-64(38-126)90(149)123-78(47(10)13-2)96(155)120-67(41-162)92(151)115-63(37-125)89(148)110-58(31-44(5)6)85(144)111-59(32-49-14-18-51(128)19-15-49)86(145)106-53(22-26-69(101)130)81(140)109-57(30-43(3)4)84(143)107-55(24-28-74(135)136)82(141)113-61(34-71(103)132)88(147)112-60(33-50-16-20-52(129)21-17-50)87(146)118-65(39-160)91(150)114-62(99(158)159)35-72(104)133/h18-26,31-36,40-47,69-70,77-88,98-118,126-130,199-203,241-242H,27-30,37-39,48-68,71-76,159-160H2,1-17H3,(H2,161,204)(H2,162,205)(H,165,171)(H,166,172)(H,168,215)(H,169,217)(H,170,216)(H,173,218)(H,174,206)(H,175,207)(H,176,208)(H,177,219)(H,178,228)(H,179,234)(H,180,237)(H,181,213)(H,182,226)(H,183,224)(H,184,227)(H,185,221)(H,186,223)(H,187,225)(H,188,220)(H,189,232)(H,190,235)(H,191,222)(H,192,236)(H,193,214)(H,194,230)(H,195,229)(H,196,231)(H,197,233)(H,209,210)(H,211,212)(H,239,240)(H4,163,164,167);14-21,43-48,53-68,76-79,125-129,160-163H,12-13,22-42,100H2,1-11H3,(H2,101,130)(H2,102,131)(H2,103,132)(H2,104,133)(H,105,139)(H,106,145)(H,107,143)(H,108,154)(H,109,140)(H,110,148)(H,111,144)(H,112,147)(H,113,141)(H,114,150)(H,115,151)(H,116,157)(H,117,142)(H,118,146)(H,119,152)(H,120,155)(H,121,134)(H,122,156)(H,123,149)(H,124,153)(H,135,136)(H,137,138)(H,158,159)/t86-,87+,88+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,126-,127-,128-,129-,130-;46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-,77-,78-,79-/m00/s1
  • Molecular Formula: C257H383 N65 O77 S6
  • Molecular Structure:CAS No:133107-64-9 Insulin (human),28B-L-lysine-29B-L-proline-

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133107-64-9 Insulin (human),28B-L-lysine-29B-L-proline-

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133107-64-9 LISPRO

  • LISPRO
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 86 21 5109 7911
  • Fax: 86 21 5109 7955
  • Address: B-5 Ecust Science Park, No. 18, Lane 1305, Hua Jing Road, Shanghai 200231 China Shanghai,ShanghaiChina
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133107-64-9 INSULIN LISPRO (5.97 MG)

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of Insulin (human),28B-L-lysine-29B-L-proline-
Title: Insulin Lispro
CAS Registry Number: 133107-64-9
CAS Name: 28B-L-Lysine-29B-L-prolineinsulin (human)
Synonyms: [Lys(B28),Pro(B29)]-insulin (human)
Manufacturers' Codes: LY-275585
Trademarks: Humalog (Lilly)
Literature References: Rapid-acting insulin analog produced in E. coli by recombinant DNA technology. Identical to human insulin except for the transposition of proline and lysine at positions 28 and 29 on the B chain. Prepn: R. E. Chance et al., EP 383472; eidem, US 5514646 (1990, 1996 both to Lilly). Study of immunogenicity: C. M. Zwickl et al., Arzneim.-Forsch. 45, 524 (1995). General pharmacology: D. R. Helton et al., ibid. 46, 91 (1996). Clinical comparison with regular human insulin: J. H. Anderson, Jr. et al., Diabetes 46, 265 (1997). Review of development and pharmacokinetics: F. Holleman, J. B. L. Hoekstra, N. Engl. J. Med. 337, 176-183 (1997); of clinical trials: V. A. Koivisto, Ann. Med. 30, 260-266 (1998). Series of articles on pharmacology and clinical experience: Acta Clin. Belg. 54, 233-254 (1999).
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Hormones/Analogs.