Home > Name List By 4 > 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl] methyl]benzoic acid China

CAS No 133040-01-4 , 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]
methyl]benzoic acid Search by region : China

  • Name: 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]
    methyl]benzoic acid
  • Synonyms: 133040-01-4;CHEBI:4814; AC1NQXXN;4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]
    methyl]benzoic acid; SKF-108566; Eprosartan (USAN/INN); SK&F-108566; CHEMBL813; SK&F 108566;
  • CAS Registry Number:
  • Flash Point: 353.3°C
  • Boiling Point: 660.6°Cat760mmHg
  • Density: 1.26g/cm3
  • Refractive index: 1.627
  • Flash Point: 353.3°C
  • Molecular Weight: 424.51266
  • InchiKey: OROAFUQRIXKEMV-LDADJPATSA-N
  • InChI: InChI=1S/C23H24N2O4S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-
    30-20)25(21)15-16-7-9-17(10-8-16)22(26)27/h4-5,7-12,14H,2-3,6,13,15H2,
    1H3,(H,26,27)(H,28,29)/b18-12+
  • Molecular Formula: C23H24N2O4S
  • Molecular Structure:CAS No:133040-01-4 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]<br />methyl]benzoic acid

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References of 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]
methyl]benzoic acid
Title: Eprosartan
CAS Registry Number: 133040-01-4
CAS Name: (aE)-a-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophenepropanoic acid
Synonyms: (E)-3-[2-butyl-1-[(4-carboxyphenyl)methyl]-imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoic acid
Manufacturers' Codes: SKF-108566
Molecular Formula: C23H24N2O4S
Molecular Weight: 424.51
Percent Composition: C 65.07%, H 5.70%, N 6.60%, O 15.08%, S 7.55%
Literature References: Prototype of the imidazoleacrylic acid angiotensin II receptor antagonists. Prepn: J. A. Finkelstein et al., EP 403159 (1990 to SmithKline Beckman); eidem, US 5185351 (1993 to SmithKline Beecham); J. Weinstock et al., J. Med. Chem. 34, 1514 (1991); R. M. Keenan et al., ibid. 36, 1880 (1993). Pharmacology: R. M. Edwards et al., J. Pharmacol. Exp. Ther. 260, 175 (1992). Receptor binding study: H. T. Schambye et al., Mol. Pharmacol. 47, 425 (1995). Clinical pharmacokinetics: D. Tenero et al., Biopharm. Drug Dispos. 19, 351 (1998). Clinical trial in hypertension: W. J. Elliott et al., J. Hum. Hypertens. 13, 413 (1999). Review of clinical experience: L. Ruilope, B. J?ger, Expert Opin. Pharmacother. 4, 107-114 (2003).
Properties: Crystals from methanol, mp 260-261°.
Melting point: mp 260-261°
 
Derivative Type: Monomethanesulfonate
CAS Registry Number: 144143-96-4
Synonyms: Eprosartan mesylate
Manufacturers' Codes: SKF-108566J
Trademarks: Teveten (Solvay)
Molecular Formula: C23H24N2O4S.CH3SO3H
Molecular Weight: 520.62
Percent Composition: C 55.37%, H 5.42%, N 5.38%, O 21.51%, S 12.32%
Properties: White to off-white crystalline powder, mp 248-250°. Insol in water. Freely sol in ethanol.
Melting point: mp 248-250°
 
Therap-Cat: Antihypertensive.
Keywords: Angiotensin II Receptor Antagonist; Antihypertensive; Imidazoleacrylic Acid Derivatives.