Home > Name List By r > Rifampicin Switzerland

CAS No 13292-46-1 , Rifampicin Search by region : Switzerland

  • Name: Rifampicin
  • Synonyms: Rifaldin; Rifoldin; Rifamate; Rifadin; Eremfat; Rimactan; rifaldazine; Rifadin I.V.; Abrifam; Riforal; Rifandin; Rifampin; Rifamycin SV; Rifobac; R/AMP; RIF; Rifater; Rimycin; Rifamycin SV Sodium; Rifa; Rifaprodin;3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin; Dipicin;Rifampicin;3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin; Rifamicin AMP;
  • CAS Registry Number:
  • Melting Point: 183 ºC (DEC.)
  • Density: 1.34 g/cm3
  • Refractive index: 1.613
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xn: Harmful;
  • HS Code: 29419000
  • EINECS: 236-312-0
  • Molecular Weight: 822.95
  • InChI: InChI=1/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
  • Risk Statements: S26;S36
  • Molecular Formula: C43H58N4O12
  • Molecular Structure:CAS No:13292-46-1 Rifampicin

Related products

Select to

13292-46-1 R-6000 RIFAMPICIN FOR CULTURAL MEDIUM USE ONLY

  • Switzerland Biosynth AG [Manufacturer]
  • Tel: +41 71 858 20 20/ 630.305.8400 (USA)
  • Fax: +41 71 858 20 30
  • Address: BIOSYNTH AG
    Rietlistrasse 4
    9422 Staad / Switzerland
    Phone: +41 (0)71 858 20 20
    Fax: +41 (0)71 858 20 30 null,nullSwitzerland
Contact Supplier

13292-46-1 RIFAMPICIN

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland null,nullSwitzerland
Contact Supplier

Select to

1/1
References of Rifampicin
Title: Rifampin
CAS Registry Number: 13292-46-1
CAS Name: 3-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin
Synonyms: 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione 21-acetate; rifampicin; rifaldazine; rifamycin AMP; R/AMP
Trademarks: Abrifam (Abbott); Eremfat (Fatol); Rifa (Grñenthal); Rifadin(e) (Aventis); Rifaldin (Aventis); Rifapiam (Piam); Rifaprodin (Almirall); Rifoldin (Aventis); Rimactan(e) (Novartis)
Molecular Formula: C43H58N4O12
Molecular Weight: 822.94
Percent Composition: C 62.76%, H 7.10%, N 6.81%, O 23.33%
Literature References: Semisynthetic antibiotic obtained by reacting 3-formylrifamycin SV with 1-amino-4-methylpiperazine in tetrahydrofuran. Prepn and structure: Maggi et al., Chemotherapia 11, 285 (1966); NL 6509961; Maggi, Sensi, US 3342810 (1966, 1967 both to Lepetit). Chemical and biological properties: Fürész, Antibiot. Chemother. 16, 316 (1970). Activity studies and clinical survey: Arioli et al., Arzneim.-Forsch. 17, 523 (1967); Pallanza et al., ibid. 529; Bergamini, ibid. 20, 1546 (1970); Dans et al., Am. J. Med. Sci. 259, 120 (1970). Metabolism: Meyer-Brunot et al., Int. Congr. Chemother. Proc., 5th, Vienna 1967 1(2), 763; Fürész et al., Arzneim.-Forsch. 17, 534 (1967); Maggi et al., ibid. 19, 651 (1969). Inhibition of protein synthesis in mammalian cells: W. C. Buss et al., Science 200, 432 (1978). Comprehensive reviews: Binda et al., Arzneim.-Forsch. 21, 1907-1978 (1971); Lester, Annu. Rev. Microbiol. 26, 88-102 (1972). Comprehensive description: G. G. Gallo, P. Radaelli, Anal. Profiles Drug Subs. 5, 467-513 (1976). Symposium on the use of rifampin in the treatment of nontuberculous infections: Rev. Infect. Dis. 5, Suppl. 3, S399-S632 (1983).
Properties: Red to orange platelets from acetone, dec 183-188°. Absorption max (pH 7.38): 237, 255, 334, 475 nm (e 33200, 32100, 27000, 15400). Rifampin is a "zwitterion" with pKa 1.7 related to the 4-hydroxy and pKa 7.9 related to the 3-piperazine nitrogen. Very stable in DMSO; rather stable in water. Freely sol in CH3Cl, DMSO; sol in ethyl acetate, methanol, tetrahydrofuran; slightly sol in water (pH <6), acetone, carbon tetrachloride. LD50 in mice, rats (mg/kg): 885, 1720 orally; 260, 330 i.v.; 640, 550 i.p. (Fürész).
pKa: pKa 1.7 related to the 4-hydroxy and pKa 7.9 related to the 3-piperazine nitrogen
Absorption maximum: Absorption max (pH 7.38): 237, 255, 334, 475 nm (e 33200, 32100, 27000, 15400)
Toxicity data: LD50 in mice, rats (mg/kg): 885, 1720 orally; 260, 330 i.v.; 640, 550 i.p. (Fürész)
Therap-Cat: Antibacterial (tuberculostatic).
Keywords: Antibacterial (Antibiotics); Ansamycins; Antibacterial (Tuberculostatic).