Home > Name List By 2 > 2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9, 10-hexahydrocycloocta[b]pyridine China

CAS No 132810-10-7 , 2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,
10-hexahydrocycloocta[b]pyridine Search by region : China

  • Name: 2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,
    10-hexahydrocycloocta[b]pyridine
  • Synonyms: AD 5423; AC1L2OS5;Lonasen;2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,
    10-hexahydrocycloocta[b]pyridine; Blonanserin (JAN/INN); Blonanserin [INN]; AD-5423; 132810-10-7; CHEBI:400585; CHEMBL178803;
  • CAS Registry Number:
  • Flash Point: 280.9 °C
  • Boiling Point: 540.8 °Cat760mmHg
  • Density: 1.095 g/cm3
  • Refractive index: 1.557
  • Flash Point: 280.9 °C
  • Molecular Weight: 367.502803
  • InchiKey: XVGOZDAJGBALKS-UHFFFAOYSA-N
  • InChI: InChI=1S/C23H30FN3/c1-2-26-13-15-27(16-14-26)23-17-21(18-9-11-19(24)12-
    10-18)20-7-5-3-4-6-8-22(20)25-23/h9-12,17H,2-8,13-16H2,1H3
  • Molecular Formula: C23H30FN3
  • Molecular Structure:CAS No:132810-10-7 2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,<br />10-hexahydrocycloocta[b]pyridine

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References of 2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,
10-hexahydrocycloocta[b]pyridine
Title: Blonanserin
CAS Registry Number: 132810-10-7
CAS Name: 2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
Manufacturers' Codes: AD-5423
Trademarks: Lonasen (Dainippon)
Molecular Formula: C23H30FN3
Molecular Weight: 367.50
Percent Composition: C 75.17%, H 8.23%, F 5.17%, N 11.43%
Literature References: Dopamine D2 and serotonin 5-HT2 receptor antagonist. Prepn: K. Hino et al., EP 385237; eidem, US 5021421 (1990, 1991 both to Dainippon). HPLC determn in plasma: M. Matsuda et al., J. Pharm. Biomed. Anal. 15, 1449 (1997). X-ray crystal structure: K. Suzuki et al., Anal. Sci. 18, 1289 (2002). In vitro receptor binding study and in vivo pharmacology in animals: M. Oka et al., J. Pharmacol. Exp. Ther. 264, 158 (1993). Evaluation in mouse models of schizophrenia: T. Nagai et al., NeuroReport 14, 269 (2003). Review of development and clinical experience: C. E. Heading, Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs 2, 79-84 (2002).
Properties: Crystals from acetonitrile, mp 123-124°.
Melting point: mp 123-124°
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Serotonin-Dopamine Antagonist.