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CAS No 131-28-2 , Benzoic acid,6-[2-[6-[2-(dimethylamino)ethyl]-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxy-

  • Name: Benzoic acid,6-[2-[6-[2-(dimethylamino)ethyl]-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxy-
  • Synonyms: o-Veratric acid,6-[[6-[2-(dimethylamino)ethyl]-2-methoxy-3,4-(methylenedioxy)phenyl]acetyl]-(8CI);Benzoicacid, 6-[[6-[2-(dimethylamino)ethyl]-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxy-(9CI); Narceine; Narcein;Benzoic acid,6-[2-[6-[2-(dimethylamino)ethyl]-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxy-; NIH 10760;
  • CAS Registry Number:
  • Density: 1.271 g/cm3
  • Refractive index: 1.578
  • EINECS: 205-021-0
  • Molecular Weight: 445.4624
  • InChI: InChI=1/C23H27NO8/c1-24(2)9-8-13-10-18-22(32-12-31-18)20(29-4)15(13)11-16(25)14-6-7-17(28-3)21(30-5)19(14)23(26)27/h6-7,10H,8-9,11-12H2,1-5H3,(H,26,27)
  • Molecular Formula: C23H27 N O8
  • Molecular Structure:CAS No:131-28-2 Benzoic acid,6-[2-[6-[2-(dimethylamino)ethyl]-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxy-

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131-28-2 Benzoic acid,6-[2-[6-[2-(dimethylamino)ethyl]-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxy-

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References of Benzoic acid,6-[2-[6-[2-(dimethylamino)ethyl]-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxy-
Title: Narceine
CAS Registry Number: 131-28-2
CAS Name: 6-[[6-[2-(Dimethylamino)ethyl]-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxybenzoic acid
Synonyms: 6-[[6-[2-(dimethylamino)ethyl]-2-methoxy-3,4-(methylenedioxy)phenyl]acetyl]-o-veratric acid
Molecular Formula: C23H27NO8
Molecular Weight: 445.46
Percent Composition: C 62.01%, H 6.11%, N 3.14%, O 28.73%
Literature References: Occurs in opium to the extent of 0.1-0.5%. The separation from morphine mother liquors is tedious: Merck, Chem. Ztg. 13, 525 (1889). Prepn from narcotine or gnoscopine: Roser, Ann. 247, 167 (1888); Frankforter, Keller, Ann. Chem. J. 22, 61 (1899); Frerichs, Arch. Pharm. 241, 259 (1903); Hope, Robinson, J. Chem. Soc. 105, 2100 (1914). Structure: Freund, Frankforter, Ann. 277, 20 (1893); Freund, Michaels, Ann. 286, 248 (1895); Freund, Ber. 40, 194 (1907); Freund, Oppenheim, Ber. 42, 1084 (1909); Addinall, Major, J. Am. Chem. Soc. 55, 1202, 2153 (1933).
Properties: The anhydr material is very hygroscopic, mp 138°. uv max (ethanol): 270 nm (log e 3.98). Usually the alkaloid is obtained as the trihydrate. Clusters of silky, prismatic needles from water, mp 176°. pKb (20°) = 10.7, pKa = 9.3. pH of satd soln = 5.8. One gram dissolves in 770 ml water, 220 ml boiling water. Moderately sol in hot alcohol, nearly insol in benzene, chloroform, ether, petr ether; sol in alkali hydroxide solns forming salts, also in dil mineral acids.
Melting point: mp 138°; mp 176°
pKa: pKb (20°) = 10.7, pKa = 9.3
Absorption maximum: uv max (ethanol): 270 nm (log e 3.98)
 
Derivative Type: Ethylnarceine hydrochloride
Synonyms: Narcyl
Molecular Formula: C25H32ClNO8
Molecular Weight: 509.98
Percent Composition: C 58.88%, H 6.32%, Cl 6.95%, N 2.75%, O 25.10%
Properties: Plates from water, mp 208-210°. Slightly sol in cold water, sol in hot water, alcohol, chloroform; insol in ether.
Melting point: mp 208-210°
 
Therap-Cat: Ethylnarceine hydrochloride as analgesic (narcotic); antitussive.
Keywords: Analgesic (Narcotic); Antitussive.